Central Project 1 (Cologne Experimental Eye Imaging Center (CEE-IC))

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The central aim of the proposed research consortium is the identification and analysis of inflammation-associated mechanisms of ocular diseases. As all projects investigate cellular processes of inflammation in particular non- or minimally-invasive intravital imaging techniques are necessary, which in real time can capture and follow up the induced alterations both in in vitro and in vivo experiments. The CEE-IC will provide an experimental imaging facility equipped with different OCT and fluorescence angiography devices together with stereomicroscopy that will enable state-of-the-art examination of the target structures without tampering the results by tissue probing or phototoxic effects. Furthermore the C1-project will provide well-established advanced vessel and particle analysis methods and will develop further standardized, highly qualitative data analysis methods in close cooperation with the individual projects. Thereby highly reliable and innovative data sets will be generated.