Central Project 1 (Cologne Experimental Eye Imaging Center (CEE-IC))

中心项目1（科隆实验眼部影像中心（CEE-IC））

• 批准号: 268736088
• 负责人: Professor Dr. Philipp Steven
• 金额: --
• 依托单位: Zentrum für Augenheilkunde
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/268736088?language=en
• 关键词: Central; Project; Cologne; Experimental; Eye

The central aim of the proposed research consortium is the identification and analysis of inflammation-associated mechanisms of ocular diseases. As all projects investigate cellular processes of inflammation in particular non- or minimally-invasive intravital imaging techniques are necessary, which in real time can capture and follow up the induced alterations both in in vitro and in vivo experiments. The CEE-IC will provide an experimental imaging facility equipped with different OCT and fluorescence angiography devices together with stereomicroscopy that will enable state-of-the-art examination of the target structures without tampering the results by tissue probing or phototoxic effects. Furthermore the C1-project will provide well-established advanced vessel and particle analysis methods and will develop further standardized, highly qualitative data analysis methods in close cooperation with the individual projects. Thereby highly reliable and innovative data sets will be generated.

提议的研究联盟的中心目标是识别和分析眼部疾病的炎症相关机制。由于所有研究炎症细胞过程的项目，特别是无创或微创的活体成像技术是必要的，它可以实时捕获和跟踪体外和体内实验中诱导的变化。CEE-IC将提供一个实验成像设备，配备不同的OCT和荧光血管造影设备，以及立体显微镜，这将使最先进的目标结构检查成为可能，而不会受到组织探针或光毒性效应的影响。此外，c1项目将提供完善的先进船舶和颗粒分析方法，并将与各个项目密切合作，进一步开发标准化、高质量的数据分析方法。因此，将产生高度可靠和创新的数据集。