Cell type-selective carriers for targeted pharmacological inhibition of Rho-/actin-dependent leukocyte recruitment into the alveolar space after blunt chest trauma (A04)

（细胞类型选择性载体靶向药物抑制Rho-/肌动蛋白依赖的白细胞募集到肺泡腔后钝性胸部创伤）侧重于策略选择性调节募集和肺泡腔巨噬细胞和中性粒细胞的功能。该项目建立在发现单核细胞/巨噬细胞选择性载体（C3botE174Q）将Rho-， actin-和cxcr2抑制剂转移到细胞中的基础上。将开发具有类似治疗选择的中性粒细胞选择性转运蛋白，并在小鼠胸腔创伤模型中确定其对炎症反应的影响。此外，造影剂的靶向递送将使MRI对细胞迁移的终生监测成为可能。

(Cell type-selective carriers for targeted pharmacological inhibition of Rho-/actin-dependent leukocyte recruitment into the alveolar space after blunt chest trauma) focuses on strategies to selectively modulate recruitment and function of both macrophages and neutrophils in the alveolar space. The project builds on the discovery of monocyte/macrophage-selective carriers (C3botE174Q) to transfer Rho-, actin-, and CXCR2-inhibitors into the cells. Neutrophil-selective transporters with similar therapeutic options will be developed and their effects on the inflammatory response determined in a murine thorax trauma model. Furthermore, targeted delivery of contrast agents will enable lifetime monitoring of cell migration by MRI.