The role of membrane recycling in plasma membrane organization (P18)

项目P18的重点是质膜（PM）的横向区室化和膜周转之间的相互作用，使用芽殖酵母作为模型系统。该小组最近发现，甲硫氨酸通透酶Mup1经历了基质依赖性构象转换，介导了PM的侧向迁移。在下一个资助期间，该小组将继续研究PM隔室和膜周转之间的相互作用，重点是（i）四跨膜蛋白对内吞货物的分离和内化的作用，以及（ii）PM胞吐作用的空间调控。

Project P18 focuses on the interplay between lateral compartmentalization of the plasma membrane (PM) and membrane turnover, using budding yeast as model system. The group recently uncovered that the methionine permease Mup1 undergoes a substrate-dependent conformational switch that mediates lateral relocation at the PM. In the next funding period the group will continue its investigation in the interplay between PM compartments and membrane turnover by focusing on (i) the role of tetraspanner proteins for segregation and internalization of endocytic cargos, and (ii) the spatial regulation and control of exocytosis at the PM.