Mitochondrial morphology regulation by dynamic Bcl-2 protein complexes (P26*)

动态 Bcl-2 蛋白复合物对线粒体形态的调节 (P26*)

• 批准号: 269889956
• 金额: --
• 依托单位: Veterinär-Physiologisch-Chemisches Institut
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/269889956?language=en
• 关键词: Mitochondrial; morphology; regulation; dynamic; Bcl

Stress-induced mitochondrial damage is confined by fusion and fission evershifting mitochondria from fragmented vesicles to hyperfused networks. Swift and reversible changes of mitochondrial morphology and clearance indicate dynamic control processes, but how mitochondrial quality control is coordinated, remains unknown. The proposed project will explore mitochondrial morphology and clearance control by Bcl-2 proteins using stabilized Bcl-2 protein conformations and quantitative confocal microscopy techniques. We aim to establish a new concept of coupling reversible conformational changes of Bcl-2 proteins to mitochondrial dynamics regulation.

应激诱导的线粒体损伤受到融合和分裂的限制，线粒体从碎片化的囊泡到超灌注的网络。线粒体形态和清除率的快速和可逆变化表明动态控制过程，但线粒体质量控制如何协调，仍然是未知的。拟议的项目将探讨线粒体形态和清除控制Bcl-2蛋白使用稳定的Bcl-2蛋白构象和定量共聚焦显微镜技术。我们的目的是建立一个新的概念耦合可逆的Bcl-2蛋白的构象变化的线粒体动力学调节。