Mitochondrial morphology regulation by dynamic Bcl-2 protein complexes (P26*)

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Stress-induced mitochondrial damage is confined by fusion and fission evershifting mitochondria from fragmented vesicles to hyperfused networks. Swift and reversible changes of mitochondrial morphology and clearance indicate dynamic control processes, but how mitochondrial quality control is coordinated, remains unknown. The proposed project will explore mitochondrial morphology and clearance control by Bcl-2 proteins using stabilized Bcl-2 protein conformations and quantitative confocal microscopy techniques. We aim to establish a new concept of coupling reversible conformational changes of Bcl-2 proteins to mitochondrial dynamics regulation.