Proteolysis of binding protein complexes regulates bioavailability of insulin-like growth factor (IGF)

我们的目标是确定血液中保持不活跃的复合体中的生长因子如何变得自由和活跃。所获得的基础知识将有助于我们了解生长因子对组织的有效性的调节，并开发新的或更有效的治疗性生长因子递送系统，这些系统可能会影响几种疾病，包括糖尿病、生长障碍和危重疾病。因此，该项目在两个层面上使澳大利亚受益：保持我们在这些重要生长调节分子研究方面的国际领先地位，以及更好地了解可能有利于澳大利亚人健康的生理机制，并为开发新的疗法提供机会。

We aim to determine how growth factors kept inactive in complexes in the blood can become free and active. The fundamental knowledge gained will help us understand the regulation of growth factors' availability to tissues and develop novel or more effective delivery systems for therapeutic growth factors that could impact on several conditions including diabetes, growth disorders and critical illness. This project therefore benefits Australia at two levels: by maintaining our international leadership in the study of these important growth-regulatory molecules, and by providing a better understanding of physiological mechanisms that might benefit the health of Australians and provide opportunities to develop novel therapeutics.