Proteolysis of binding protein complexes regulates bioavailability of insulin-like growth factor (IGF)

结合蛋白复合物的蛋白水解调节胰岛素样生长因子 (IGF) 的生物利用度

• 批准号: DP0771559
• 负责人: Dr Sue Firth
• 金额: $ 16.24万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0771559
• 关键词: Proteolysis; binding; protein; complexes; regulates

We aim to determine how growth factors kept inactive in complexes in the blood can become free and active. The fundamental knowledge gained will help us understand the regulation of growth factors' availability to tissues and develop novel or more effective delivery systems for therapeutic growth factors that could impact on several conditions including diabetes, growth disorders and critical illness. This project therefore benefits Australia at two levels: by maintaining our international leadership in the study of these important growth-regulatory molecules, and by providing a better understanding of physiological mechanisms that might benefit the health of Australians and provide opportunities to develop novel therapeutics.

我们的目标是确定如何保持在血液中的复合物中不活跃的生长因子可以变得自由和活跃。所获得的基础知识将帮助我们了解生长因子对组织的可用性的调节，并为治疗性生长因子开发新的或更有效的递送系统，这些生长因子可能会影响包括糖尿病，生长障碍和危重病在内的多种疾病。因此，该项目在两个层面上使澳大利亚受益：通过保持我们在这些重要的生长调节分子研究方面的国际领导地位，以及通过更好地了解可能有益于澳大利亚人健康的生理机制，并提供开发新疗法的机会。