APTERA II - Electromagnetic THz- and mm-wave Sensors for African Trypanosomes using RNA Aptamer-Derivatized Surface Layers
APTERA II - 使用 RNA 适体衍生表面层的非洲锥虫电磁太赫兹和毫米波传感器
基本信息
- 批准号:272601967
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Priority Programmes
- 财政年份:2015
- 资助国家:德国
- 起止时间:2014-12-31 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The goal of our collaborative research effort is the development of an electromagnetic (EM) sensor device for the detection of African trypanosomes. Trypanosomes are single cell organisms that cause African trypanosomiasis, a parasitic disease that is also known as African sleeping sickness. If left untreated, sleeping sickness is fatal and thus, the early detection of parasite cells in the blood and/or the cerebrospinal fluid of infected patients is for health workers and clinicians crucial. As initially proposed, the EM-sensors operate in the mm- and THz-frequency region and in order to facilitate the binding of parasites to the sensory surface they are covalently functionalized with so-called aptamer molecules. Aptamers are synthetic, biomolecular affinity reagents, which in this case have been designed to specifically adhere to the surface of trypanosome cells. In the 1st funding period we were able to demonstrate the general applicability of our EM-aptasensor approach and for the 2nd funding period we now propose to use the generated data and knowledge to make the next steps towards a first prototype diagnostic device. Specifically, we intend to increase the sensitivity of the sensory surface to lower the detection limit to be able to detect even very low numbers of parasites. Furthermore, we suggest to extend our detection principle to "wet conditions" to be able to handle and measure "true" biological samples such as trypanosome-infected blood or serum specimen. The electromagnetic properties of these “wet samples” will be thoroughly characterised. We consider spoof plasmonic structures and a special system of two coupled resonators to achieve increased sensitivity and the ability to measure under wet conditions with high losses due to the water. We also propose to expand our investigation into more sophisticated aptamer-derivatized surfaces such as multifunctional and multilayered aptamer surfaces and we propose to generate aptamer/nanobody hybrid surfaces to potentially lower the detection limit even further. The proposal includes all necessary steps to demonstrate “proof-of-principle” of the EM-aptasensor approach and is intended to provide the groundwork for the design of a prototype-device for a fast, robust and low cost detection of African sleeping sickness. The construction of a first integrated chip that contains next to the aptasensor all the necessary electronic circuitry for signal generation and detection is planned as part of a cooperative effort together with Prof. Kissinger.
我们合作研究的目标是开发一种用于检测非洲锥虫的电磁(EM)传感器设备。锥虫是引起非洲锥虫病的单细胞生物体,这是一种寄生虫病,也被称为非洲昏睡病。如果不加以治疗,昏睡病是致命的,因此,早期检测感染患者血液和/或脑脊液中的寄生虫细胞对卫生工作者和临床医生至关重要。正如最初提出的,EM传感器工作在毫米和太赫兹频率区域,为了促进寄生虫与感觉表面的结合,它们与所谓的适体分子共价功能化。适配子是人工合成的生物分子亲和剂,在这种情况下,它被设计成专门附着在锥虫细胞的表面。在第一个资助期,我们能够展示我们的EM-aptasenser方法的一般适用性,在第二个资助期,我们现在建议使用生成的数据和知识来为第一个原型诊断设备采取下一步步骤。具体地说,我们打算提高感官表面的灵敏度,以降低检测下限,以便能够检测到即使是非常少量的寄生虫。此外,我们建议将我们的检测原理扩展到“潮湿条件”,以便能够处理和测量“真实”的生物样本,如锥虫感染的血液或血清样本。这些“湿样品”的电磁特性将得到彻底的描述。我们考虑了伪等离子激元结构和两个耦合谐振器的特殊系统,以实现更高的灵敏度和在潮湿条件下测量因水造成的高损失的能力。我们还建议将我们的研究扩展到更复杂的适配子衍生表面,如多功能和多层适配子表面,并建议生成适配子/纳米体混合表面以潜在地进一步降低检测下限。该提案包括所有必要的步骤,以证明EM-aptasenser方法的“原则证明”,并旨在为设计一种快速、可靠和低成本检测非洲昏睡病的原型装置奠定基础。建造第一个集成芯片的计划是与基辛格教授合作的一部分,该芯片在适配子传感器旁边包含信号产生和检测所需的所有电子电路。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Professor Dr.-Ing. Christian Damm其他文献
Professor Dr.-Ing. Christian Damm的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Professor Dr.-Ing. Christian Damm', 18)}}的其他基金
Tunable Gradient-Index Fishnet for Beam Steering Applications at 60 GHz
适用于 60 GHz 波束控制应用的可调谐梯度折射率渔网
- 批准号:
350604071 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Research Grants
Tunable Gradient Index Fishnet Structures based on Liquid Crystals for Beam Steering Applications
用于光束转向应用的基于液晶的可调梯度折射率鱼网结构
- 批准号:
230900032 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Research Grants
Planar tunable metamaterials for microwave applications, including matching circuits and leaky wave antennas based on liquid crystals
用于微波应用的平面可调谐超材料,包括基于液晶的匹配电路和漏波天线
- 批准号:
167882667 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Research Grants
相似国自然基金
药用植物华泽兰中改善II型糖尿病并发抑郁症活性先导化合物的挖掘及其作用机制研究
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
脂肪干细胞外泌体调节Bax/BAK1-caspase-3/caspase8信号轴影响II型肺泡上皮细胞衰老在脓毒症肺损伤中的作用及机制
- 批准号:MS25H010004
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
超长波长NIR-II 区有机探针的开发及在活体检测中的应用
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
αvβ3整合素靶向有机探针用于NIR-II FL/MRI双模态成像引导的三阴性乳腺癌光热治疗研究
- 批准号:2025JJ81013
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
全钒液流电池负极V(II)/V(III)电化学氧化还原的催化机理研究
- 批准号:2025JJ50094
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
1 类新药研发后补助(治疗用生物制品 1 类 MG-K10 人源化单抗注射液、II 期临床试验)
- 批准号:2025JK2095
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
1 类新药研发后补助(治疗用生物制品 1 类MG-ZG122 人源化单抗注射液、II 期临床试验)
- 批准号:2025JK2097
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
黏土矿物结构Fe(II)跨界面驱动氧化铁结合态有机质释放和转化机制
- 批准号:2025JJ50205
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
有序组装型NIR-II荧光探针的构建及疾病辅助诊断应用
- 批准号:2025JJ40014
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
NIR-II荧光内镜辅助胰腺癌术中肿瘤活性评估的可视化研究
- 批准号:2025JJ50653
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
相似海外基金
SBIR Phase II: Modular And Reconfigurable Electromagnetic Navigation System For Surgical Interventions And Medical Robotics
SBIR 第二阶段:用于外科手术和医疗机器人的模块化和可重构电磁导航系统
- 批准号:
2222580 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Cooperative Agreement
Phase II IUCRC at University of Hawaii: Center for Electromagnetic Compatibility (CEMC); University of Hawaii in Electromagnetic Technologies
夏威夷大学 IUCCRC 第二阶段:电磁兼容性中心 (CEMC);
- 批准号:
1822213 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Continuing Grant
The Belle-II Electromagnetic Calorimeter Endcap
Belle-II 电磁热量计端盖
- 批准号:
SAPEQ-2014-00009 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Subatomic Physics Envelope - Research Tools and Instruments
I/UCRC Phase II: Center for Electromagnetic Compatibility
I/UCRC 第二阶段:电磁兼容性中心
- 批准号:
1440110 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Continuing Grant
I/UCRC Phase II: Center for Electromagnetic Compatibility
I/UCRC 第二阶段:电磁兼容性中心
- 批准号:
1440107 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Continuing Grant
SBIR Phase II: Location Aware Computing Using Near Field Electromagnetic Ranging
SBIR 第二阶段:使用近场电磁测距进行位置感知计算
- 批准号:
0646339 - 财政年份:2007
- 资助金额:
-- - 项目类别:
Standard Grant
SBIR Phase II: Nanocrystalline Fe-Co For Electromagnetic Interference (EMI) Suppression
SBIR 第二阶段:用于电磁干扰 (EMI) 抑制的纳米晶铁钴
- 批准号:
0239008 - 财政年份:2003
- 资助金额:
-- - 项目类别:
Standard Grant
SBIR/STTR Phase II: Integration of Electromagnetic Actuation Using VOST Design
SBIR/STTR 第二阶段:使用 VOST 设计集成电磁驱动
- 批准号:
0215960 - 财政年份:2002
- 资助金额:
-- - 项目类别:
Standard Grant
SBIR Phase II: A High Frequency Beam Steered Electromagnetic Impulse Radar to Locate Human Targets Through Opaque Media
SBIR 第二阶段:高频波束控制电磁脉冲雷达通过不透明介质定位人体目标
- 批准号:
0216574 - 财政年份:2002
- 资助金额:
-- - 项目类别:
Standard Grant
Effects of Electromagnetic Radiation on the Plastic Deformation of II-VI Compounds
电磁辐射对 II-VI 化合物塑性变形的影响
- 批准号:
9730304 - 财政年份:1998
- 资助金额:
-- - 项目类别:
Continuing Grant