GRK 484: Signalling Systems and Gene Expression in Developmental Model Systems

发育生物学是生命科学中最繁荣的学科之一，这要归功于分子生物学和遗传学的大量新方法和见解。它处理迷人的问题，与医学（例如癌症研究）和应用生物学（例如转基因生物的产生）有关。博士生在以下领域之一进行研究：（1）染色体蛋白质在细胞类型和器官特异性基因表达的编程和永久固定中的作用。(2)通过信号分子如形态发生素、诱导剂、生长因子和激素控制基因表达。(3)位置依赖基因表达与生物模式形成。(4)识别参与引导神经纤维到达其目标的识别分子，或在移植中区分自我和非自我。此外，学生们有机会熟悉已成为现代生物学模型系统的生物体，如小鼠，鸡，鱼（Danio或Medaka），爪蟾，果蝇，秀丽隐杆线虫，水螅和水螅。学生们将看到转基因小鼠是如何产生的，并熟悉许多分子生物学方法。在培训计划中，优先考虑实践课程。培训计划的跨学科性质是由任命的科学家参与机构，如欧洲分子生物学实验室EMBL，德国癌症研究中心，马克斯普朗克医学研究所，以及分子生物学，神经生物学或科学计算大学的跨学科中心。

Developmental biology is one of the most flourishing disciplines of Life Sciences thanks to the flood of new methods and insights from molecular biology and genetics. It deals with fascinating problems, is related to medicine (e.g. cancer research) and applied biology (e.g. generation of transgenic organisms). The PhD students do research in one of the following fields: (1) Role of chromosomal proteins in the programming and permanent fixation of cell-type and organ-specific gene expression. (2) Control of gene expression by signal molecules such as morphogens, inducers, growth factors and hormones. (3) Position-dependent gene expression and biological pattern formation. (4) Identification of recognition molecules involved in the guidance of nerve fibres to their targets, or in the discrimination between self and non-self in transplants. In addition, the students have the opportunity to become acquainted with organisms that have become model systems in modern biology such as the mouse, chicken, fish (Danio or Medaka), Xenopus, Drosophila, Caenorhabditis elegans, Hydra and Hydractinia. The students see how transgenic mice are generated and become familiar with many methods of molecular biology. In the training program priority is given to practical courses. The interdisciplinary character of the training program is warranted by the participation of scientists appointed to institutions such as the European Molecular Biology Laboratory EMBL, the German Cancer Research Centre, the Max Planck Institute for Medical Research, and the Interdisciplinary Centres of the university for Molecular Biology, Neurobiology or Scientific Computing.