Mathematical modelling of the early stages of multicellular evolution

多细胞进化早期阶段的数学模型

• 批准号: DE160100690
• 负责人: Dr Andrew Black
• 金额: $ 25.86万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-03-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE160100690
• 关键词: Mathematical; modelling; early; stages; multicellular

This project aims to develop new mathematical methodology to understand the early stages of the evolution of multicellular organisms from unicellular ancestors. This is the best known example of the creation of a new level of biological organisation. However, the early stages of this transition are poorly understood, especially how early groups of cells came to possess Darwinian characteristics, which then allows natural selection to act on them. It is anticipated that the models produced will be used to give the first mechanistic account of this intrinsically stochastic, multi-level, phenomenon. This may lead to new insights into the emergence and subsequent evolution of simple multicellular life cycles and early forms of development.

该项目旨在开发新的数学方法，以了解多细胞生物从单细胞祖先进化的早期阶段。这是创造一个新的生物组织水平的最著名的例子。然而，人们对这种转变的早期阶段知之甚少，特别是早期细胞群如何具有达尔文特征，从而允许自然选择对其进行作用。预计产生的模型将被用来给这个本质上随机的，多层次的现象的第一个机械帐户。这可能会导致对简单多细胞生命周期和早期发育形式的出现和随后的进化的新见解。