Transcutaneous immunization: Mechanisms of intercellular crosstalk in the skin (A05)

经皮免疫：皮肤细胞间串扰的机制（A05）

• 批准号: 273643419
• 金额: --
• 依托单位: Institut für Immunologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/273643419?language=en
• 关键词: Transcutaneous; immunization; Mechanisms; intercellular; crosstalk

We have established a method for transcutaneous immunization (TCI) based on the Toll-like receptor 7-agonist imiquimod that is applied along with a synthetic CD8 T cell epitope onto intact murine skin. In continuation of our previous work, we will address the contribution of myeloid cell populations in the skin, i.e. dendritic cells, macrophages, neutrophils and mast cells to decipher cells and mediators acting positively or negatively on TCI-induced immune responses. As a long term perspective, we will pursue the aim to improve the efficiency of TCI and the generation of T cell memory.

我们已经建立了一种基于Toll样受体7激动剂咪喹莫特的经皮免疫（TCI）方法，所述咪喹莫特与合成的CD8 T细胞表位一起沿着应用于完整的小鼠皮肤上。在继续我们以前的工作，我们将解决的贡献，骨髓细胞群体在皮肤中，即树突状细胞，巨噬细胞，嗜中性粒细胞和肥大细胞，以破译细胞和介质积极或消极地作用于TCI诱导的免疫反应。从长远来看，我们将致力于提高TCI的效率和T细胞记忆的产生。