Targets and mediators of IL-17 in mouse models of psoriasis and skin infection (C01)

银屑病和皮肤感染小鼠模型中 IL-17 的靶点和介质 (C01)

• 批准号: 273670687
• 金额: --
• 依托单位: Universitäts-Hautklinik
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/273670687?language=en
• 关键词: Targets; mediators; IL; 17; mouse

The IL-17 response plays a major role in the defense against S. aureus but also in the pathogenesis of psoriasis. As we are interested in the specific mechanism of IL-17 induction and its downstream pathways we will (i) investigate how T cells expressing IL-17 are induced by S. aureus infections; (ii) analyze the keratinocyte gene expression response to IL-17 in different models of psoriasis as well as in S. aureus infection; (iii) investigate the role of the MALT1-NFκB pathway and the NIK non-canonical NFκB pathway in the keratinocyte response to IL-17A.

IL-17应答在金黄色葡萄球菌的防御中起着重要作用，也在银屑病的发病机制中起着重要作用。由于我们对IL-17诱导及其下游途径的具体机制很感兴趣，我们将(I)研究金黄色葡萄球菌感染如何诱导表达IL-17的T细胞；(Ii)分析不同银屑病模型以及金黄色葡萄球菌感染过程中角质形成细胞对IL-17的基因表达反应；(Iii)研究MALT1-NFκB通路和NIK非典范核因子κB通路在角质形成细胞对IL-17A应答中的作用。