权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The effect of a ketogenic diet (KD) - a very low carbohydrate and high-fat diet - without caloric restrictions on endurance capacity in healthy adults

生酮饮食 (KD)（一种极低碳水化合物和高脂肪饮食）对健康成年人耐力能力的影响，无热量限制

基本信息

批准号：
274452328
负责人：
Professor Dr. Hartmut Bertz
金额：
--
依托单位：
Institut für Bewegungs- und Arbeitsmedizin
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2015
资助国家：
德国
起止时间：
2014-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/274452328?language=en
关键词：
effect ketogenic diet KD very

项目摘要

The ketogenic diet (KD) is a very low carbohydrate, high-fat and adequate-protein diet that without limiting calories, induces a metabolic condition called ketosis, a state of elevated levels of ketone bodies in the blood. There is one traditional diet known to have been essentially free of carbohydrates, namely that of the Inuits, their diet consisted over generations mainly of mammals, fish and birds and nearly no vegetables. A KD was first introduced in our society to treat epilepsy in the 1920s and has become quite popular in recent decades as a weight-loss diet. A KD inhibits insulin secretion most straightforwardly via the ingestion of very few carbohydrates. An insulin-inhibition diet was proven effective in experimental animal models targeting tumour energy metabolism. Although there is too little scientific evidence currently to recommend a KD in cancer patients (larger trials are ongoing), an increasing number of cancer patients put themselves on a KD outside of clinical trials and often without medical supervision in response to frequent press reports and health books about the positive potential of KDs. Regular physical exercise during and after anti-cancer therapy has been associated with many health benefits, ranging from improvements in quality of life and cancer-related fatigue, to the reduction in cancer recurrences and mortality among several cancers. Therefore, any diet that may compromise physical performance and the patient s capacity to adhere to an exercise regime would be of great concern. Furthermore, there is already evidence of the potential for KDs to deplete muscle and liver glycogen stores and to trigger symptomatic side-effects of weakness and fatigue. In the literature to date, there is limited data focusing on the effect of a KD outside weight-loss studies (caloric restriction) and involving a long enough intervention duration to overcome the metabolic adaption phase to chronically low-carbohydrate intake (1-2 week) on physical performance. Therefore, the major objective of the proposed study is to firstly assess whether the application of a KD without caloric restriction leads to a loss of physical performance (endurance capacity and muscle strength) in healthy adults. The experimental intervention of this before-and-after comparison trial in 50 healthy adults consists of a KD lasting 6 weeks with a previous preparation period consisting of detailed instructions during regular classes over a 3-week period on how to follow a KD. The primary outcome measure will be the maximum rate of oxygen consumption to exhaustion as measured during graded bicycle exercise. VO2max reflects an individual s aerobic physical fitness and is a key determinant of endurance capacity. Key secondary outcome measures are strength, body composition and metabolic parameters.

生酮饮食(KD)是一种非常低碳水化合物、高脂肪和充足蛋白质的饮食，不限制卡路里，会导致一种称为酮病的代谢状况，即血液中酮体水平升高的状态。有一种已知的传统饮食基本上不含碳水化合物，那就是因纽特人，他们的饮食世代以来主要由哺乳动物、鱼类和鸟类组成，几乎没有蔬菜。KD在20世纪20年代首次被引入到我们的社会中来治疗癫痫，并在最近几十年作为一种减肥饮食变得非常流行。糖尿病肾病通过摄入极少的碳水化合物，最直接地抑制胰岛素的分泌。在针对肿瘤能量代谢的实验动物模型中，胰岛素抑制饮食被证明是有效的。尽管目前几乎没有科学证据建议癌症患者使用KD(更大规模的试验正在进行中)，但越来越多的癌症患者在临床试验之外使用KD，而且往往没有医疗监督，以回应关于KDS积极潜力的频繁新闻报道和健康书籍。在抗癌治疗期间和之后，定期锻炼与许多健康益处有关，从改善生活质量和癌症相关的疲劳，到减少癌症复发和几种癌症的死亡率。因此，任何可能损害体能和患者S坚持锻炼方案的能力的饮食都将是非常值得关注的。此外，已经有证据表明，KDS有可能耗尽肌肉和肝脏的糖原储备，并引发虚弱和疲劳的症状副作用。在迄今为止的文献中，有有限的数据集中在外部减肥研究(卡路里限制)和涉及足够长的干预持续时间以克服长期低碳水化合物摄入(1-2周)对身体表现的代谢适应阶段的KD的影响。因此，这项研究的主要目的是首先评估不限制热量摄入的KD是否会导致健康成年人的身体表现(耐力和肌肉力量)的丧失。这项在50名健康成人中进行的前后对比试验的实验干预包括持续6周的KD和之前的准备阶段，其中包括在3周的常规课程中如何遵循KD的详细指导。主要的结果测量将是在分级自行车运动中测量的最大耗氧率到疲劳率。最大摄氧量反映了S个人的有氧身体素质，是耐力的关键决定因素。关键的次要结果指标是力量、身体成分和代谢参数。