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OptoFluidic Adaptive Optics (OFAO)

光流控自适应光学 (OFAO)

基本信息

批准号：
274458620
负责人：
Professor Dr. Caglar Ataman
金额：
--
依托单位：
Institut für Mikrosystemtechnik (IMTEK)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2016
资助国家：
德国
起止时间：
2015-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/274458620?language=en
关键词：
OptoFluidic Adaptive Optics OFAO

项目摘要

OptoFluidic Adaptive Optics (OFAO) envisions an unprecedented refractive adaptive optics system featuring a reconfigurable freeform membrane as the spatial phase modulator. Employed primarily in ground-based telescopes for atmospheric turbulence compensation, adaptive optics (AO) has long proven to be a costly yet powerful enabler of diffraction limited imaging through turbulent media. A plethora of life science microscopy methods both in confocal and full-field modalities have also adapted AO in recent years to enhance resolution as well as contrast in deep tissue imaging. Despite very promising results, widespread acceptance of AO is impeded primarily by the excessive cost. All practical AO systems share the same basic architecture of a reflective deformable mirror and a wavefront sensor combined in an intricate yet expensive optical arrangement. We propose a completely new approach to adaptive optics, which has the potential to significantly expand the application area of AO. To achieve this goal, OFAO will be active in the following topics:- Adaptive refractive surfaces capable of arbitrary wavefront correction: A cavity filled with an optical liquid and sealed by an elastic polymer constitutes the basic arrangement that OFAO will use. Using ITO, an electrically active yet optically transparent layer of many electrodes can deform the membrane in the desired shape; given the polymer membrane is conductive. An alternative approach is to use insulating membrane material and use an ionic liquid as the optical liquid. - Sensorless wavefront estimation using the information inherent in the image: Both for confocal and full-field microscopy, there now exist efficient algorithms that use the image plane information to estimate the wavefront distortion. OFAO will capitalize on these methods to eliminate the wavefront sensor and attain a fully in-line AO system compatible for majority of life science microscopy methods.- Control algorithms and electronics: For life-sciences, dynamic real-time imaging is as crucial as the imaging quality; therefore performing wavefront correction at a speed comparable to conventional AO systems is another major goal of OFAO. The challenge here is to translate the computed wavefront distortion into mechanical membrane profile, which will be addressed by both a software interface and high voltage driving electronics. OFAOs refractive adaptive optics system will not only simplify AO for life science microscopy, but also unravel new opportunities through miniaturization. The OFAO approach offers an ideal solution by bringing AO down to the objective level. Coupled with a software-based wavefront estimation algorithm and an external driving box connected to it via a simple interface, such an AO objective would elevate a conventional microscope to an AO microscope, capable of correcting sample-induced, environmental and illumination-related wavefront errors.

光流体自适应光学（OFAO）设想了一种前所未有的折射自适应光学系统，其特征是可重构的自由形状薄膜作为空间相位调制器。自适应光学（AO）主要用于地面望远镜的大气湍流补偿，长期以来一直被证明是一个昂贵的，但强大的使能器的衍射限制成像通过湍流介质。近年来，大量的共焦和全场模式的生命科学显微镜方法也适应了AO，以提高深层组织成像的分辨率和对比度。尽管结果非常有希望，但AO的广泛接受主要受到过高成本的阻碍。所有实际的AO系统共享相同的基本架构的反射变形镜和波前传感器组合在一个复杂的但昂贵的光学布置。我们提出了一种全新的方法，自适应光学，这有可能显着扩大AO的应用领域。为了实现这一目标，OFAO将积极参与以下主题：-能够进行任意波前校正的自适应折射表面：填充有光学液体并由弹性聚合物密封的腔体构成OFAO将使用的基本布置。使用ITO，许多电极的电活性但光学透明的层可以使膜变形为所需的形状;假定聚合物膜是导电的。另一种方法是使用绝缘膜材料并使用离子液体作为光学液体。- 使用图像中固有的信息进行无传感器波前估计：对于共焦和全场显微镜，现在存在使用图像平面信息来估计波前失真的有效算法。OFAO将利用这些方法来消除波前传感器，并实现与大多数生命科学显微镜方法兼容的完全在线AO系统。控制算法和电子学：对于生命科学，动态实时成像与成像质量一样重要;因此，以与传统AO系统相当的速度执行波前校正是OFAO的另一个主要目标。这里的挑战是将计算的波前畸变转化为机械膜轮廓，这将通过软件接口和高压驱动电子器件来解决。OFAOs折射自适应光学系统不仅将简化AO的生命科学显微镜，但也揭示了新的机会，通过小型化。OFAO方法通过将AO降低到客观水平提供了理想的解决方案。结合基于软件的波前估计算法和通过简单接口连接到其的外部驱动盒，这种AO物镜将传统显微镜提升为AO显微镜，能够校正样品引起的、环境和照明相关的波前误差。