Enzymes of the sphingolipid metabolism as potential prognostic markers for breast cancer patients - and the impact of a anti-hormone therapy

鞘脂代谢酶作为乳腺癌患者潜在的预后标志物 - 以及抗激素治疗的影响

• 批准号: 274771287
• 负责人: Dr. Marthe-Susanna Wegner
• 金额: --
• 依托单位: Institut für Klinische Pharmakologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/274771287?language=en
• 关键词: Enzymes; sphingolipid; metabolism; potential; prognostic

Expression, protein level and activity of enzymes of the sphingolipid metabolism, especially ceramide synthases, after hormone, SERM and SERD treatment in estrogen receptor positive and negative breast cancer cells is to be analyzed and therefore the potential as prognostic marker of breast cancer patients is determined. Therefore molecular mechanisms, which lead to a hormone-dependent altered expression of these enzymes in breast cancer tumors and the impact of a anti-hormone therapy on the expression of these enzymes are to be investigated. Additionally, the impact of these alterations on the breast cancer cell growth and whether the enzymes of the sphingolipid metabolism are a potential therapeutic target in breast cancer tumors is to be analyzed.

分析雌激素受体阳性和阴性乳腺癌细胞在激素、SERM和SERD治疗后鞘脂代谢酶，特别是神经酰胺合成酶的表达、蛋白水平和活性，从而确定其作为乳腺癌患者预后指标的潜力。因此，导致这些酶在乳腺癌肿瘤中激素依赖性表达改变的分子机制以及抗激素治疗对这些酶表达的影响有待研究。此外，这些改变对乳腺癌细胞生长的影响以及鞘脂代谢酶是否为乳腺癌肿瘤的潜在治疗靶点还有待分析。

项目成果

GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.

• DOI: 10.1016/j.biocel.2019.05.002
• 发表时间: 2019-07
• 期刊: The international journal of biochemistry & cell biology
• 作者: Marthe-Susanna Wegner;L. Gruber;Nina Schömel;S. Trautmann;Sebastian Brachtendorf;D. Fuhrmann;Y. Schreiber;Catherine Olesch;B. Brüne;G. Geisslinger;S. Grösch

UGCG influences glutamine metabolism of breast cancer cells

• DOI: 10.1038/s41598-019-52169-7
• 发表时间: 2019-10-30
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Schoemel, Nina;Hancock, Sarah E.;Wegner, Marthe-Susanna
• 通讯作者: Wegner, Marthe-Susanna

Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes

• DOI: 10.1038/s41598-018-37342-8
• 发表时间: 2019-01
• 期刊: Scientific Reports
• 影响因子: 4.6
• 作者: Jennifer Kurz;J. Barthelmes;L. Blum;T. Ulshöfer;Marthe-Susanna Wegner;N. Ferreirós;Luise A Roser;G. Geisslinger;S. Grösch;S. Schiffmann

UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells

• DOI: 10.1007/s00018-018-2799-7
• 发表时间: 2018-03
• 期刊: Cellular and Molecular Life Sciences
• 影响因子: 8
• 作者: Marthe-Susanna Wegner;Nina Schömel;L. Gruber;Stephanie Beatrice Örtel;M. Kjellberg;P. Mattjus;Jennifer Kurz;S. Trautmann;B. Peng;Martin Wegner;M. Kaulich;R. Ahrends;G. Geisslinger;S. Grösch