Tipping the balance: Immune-mediated pathologies in CVID enteropathy (A04 (P07))

打破平衡：CVID 肠病中免疫介导的病理学 (A04 (P07))

• 批准号: 275518535
• 金额: --
• 依托单位: Centrum für Chronische Immundefizienz (CCI)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/275518535?language=en
• 关键词: Tipping; balance; Immune; mediated; pathologies

Immune-mediated gastrointestinal disease is a severe complication in patients with common variable immunodeficiency. The current findings suggest a dysbalance of T cell mediated immunity in the context of hypogammaglobulinemia affecting the local IgA production and microbiome causing the enteropathy. By the cross-sectional and longitudinal analysis of central factors in the local, dysregulated interferon network, the TCR specificity of infiltrating T cells and comparison to autoimmune enteropathy and gastrointestinal graft-versus-host disease, the project aims to improve diagnostics and to define targets for treatment.

免疫介导的胃肠道疾病是常见的可变免疫缺陷患者的严重并发症。目前的研究结果表明，在低丙种球蛋白血症的情况下，T细胞介导的免疫功能失衡，影响局部伊加的产生和微生物组，导致肠道疾病。通过对局部失调的干扰素网络中的中心因素、浸润性T细胞的TCR特异性以及与自身免疫性肠病和胃肠道移植物抗宿主病的比较的横截面和纵向分析，该项目旨在改善诊断并确定治疗目标。