The function of truncated MEK1 protein in a G2 phase cell cycle delay and in mitosis. Understanding cell proliferation.

控制细胞生长的细胞内信号传导途径通常在癌症和其他过度增殖性疾病中突变。准确了解这些途径如何运作以及这些途径的突变如何导致不受控制的生长，可以很容易地为预防性治疗或治愈提供新的靶点。 我们已经确定了一种新的机制，调节一个充分研究的途径，MAPK途径的一个组成部分，和这个组成部分的新功能。 这种新组分对先前通过经典MAPK途径控制的调节细胞生长的机制的贡献可能会改变我们对控制细胞生长的基本机制的理解。

Intracellular signaling pathways controlling cell growth are often mutated in cancers and other hyperproliferative diseases. Understanding precisely how these pathways operate and how mutations of these pathways can contribute to uncontrolled growth can readily provide new targets for preventative therapies or cures. We have identified a novel mechanism regulating one component of a well studied pathway, the MAPK pathway, and new functions for this component. The contribution of this novel component to mechanisms involved in regulating cell growth previously through to be controlled by the canonical MAPK pathway could change our understanding of the fundamental mechanisms controlling cell growth.