The function of truncated MEK1 protein in a G2 phase cell cycle delay and in mitosis. Understanding cell proliferation.

截短的 MEK1 蛋白在 G2 期细胞周期延迟和有丝分裂中的功能。

• 批准号: DP0771404
• 负责人: Prof Brian Gabrielli
• 金额: $ 18.25万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0771404
• 关键词: function; truncated; MEK1; protein; G2

Intracellular signaling pathways controlling cell growth are often mutated in cancers and other hyperproliferative diseases. Understanding precisely how these pathways operate and how mutations of these pathways can contribute to uncontrolled growth can readily provide new targets for preventative therapies or cures. We have identified a novel mechanism regulating one component of a well studied pathway, the MAPK pathway, and new functions for this component. The contribution of this novel component to mechanisms involved in regulating cell growth previously through to be controlled by the canonical MAPK pathway could change our understanding of the fundamental mechanisms controlling cell growth.

在癌症和其他增生性疾病中，控制细胞生长的细胞内信号通路经常发生突变。准确了解这些通路是如何运作的，以及这些通路的突变如何导致不受控制的增长，很容易为预防性治疗或治疗提供新的靶点。我们已经确定了一种新的机制来调节一个已经研究得很好的途径的一个成分，MAPK途径，以及这个成分的新功能。这一新的成分对以前通过规范的MAPK途径调控细胞生长的机制的贡献可能会改变我们对控制细胞生长的基本机制的理解。