Synthetic lethality screen targeting a defective checkpoint in melanoma

针对黑色素瘤检查点缺陷的综合致死筛查

• 批准号: nhmrc : 1029260
• 负责人: Prof Brian Gabrielli
• 金额: $ 36.82万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/synthetic-lethality-screen-checkpoint-melanoma/110680
• 关键词: Synthetic; lethality; screen; targeting; defective

All cancers have defects in the mechanisms that regulate normal cell growth and division. These defects provide a growth advantage for the cancer, but can also be an Achilles Heel. In this project we will investigate targeting a defective control mechanism we found in a high proportion of melanomas. We will identify genes that when inhibited combine with the defective control to specifically kill tumour cells with this defect. Normal tissue is protected by its intact regulatory mechanism.

所有的癌症在调节正常细胞生长和分裂的机制上都有缺陷。这些缺陷为癌症提供了生长优势，但也可能是阿喀琉斯之踵。在这个项目中，我们将研究针对一个有缺陷的控制机制，我们发现在一个高比例的黑色素瘤。我们将鉴定当被抑制时与缺陷对照联合收割机结合以特异性地杀死具有该缺陷的肿瘤细胞的基因。正常组织受到其完整的调节机制的保护。