Binding principles of silicic acid by carbohydrates

碳水化合物是硅的合适螯合配体，以建立水解稳定的Si <$O <$C键。在这一领域，高价的硅络合物（配位数5和6）在强碱性溶液中稳定，但在生理pH值条件下不稳定，因此它们在硅的生物化学中不具有相关性。因此，它是这个项目的目的是合成（水解稳定）四配位碳水化合物-硅化合物，Si（OR）4，代表新的Si 1的仿生生产的二氧化硅衍生物作为生物化学中可能的运输形式的积木。第一部分涉及合成这些物种的规则和概念的认识，以深入了解其结构和键合的原理，包括建立合适的光谱方法进行检测（特别是通过NMR方法）。第二部分应该证明在硅的生物化学中获得的知识的有用性，也就是说，每个新识别的基序都应该在真实的生物分子上进行测试。我们合成感兴趣的物种的策略是提供基于碳水化合物的O原子模式，以确保硅的螯合而没有任何应变。根据DFT计算，有足够的证据表明这种结构应该是可获得的。

Carbohydrates are suitable chelating ligands for silicon to establish hydrolytically stable Si¿O¿C bonds. In this field ¿hypervalent¿ silicon complexes (coordination number five and six) are stable in strongly alkaline solution but unstable under the conditions of a physiological pH value and therefore they should possess no relevance in the biochemistry of silicon. Thus it is the aim of this project to synthesise (hydrolytically stable) tetracoordinate carbohydrate-silicon compounds, Si(OR)4, representing novel Si1 building blocks for biomimetic production of silica derivatives as possible transport forms in biochemistry. One part deals with the recognition of rules and concepts for synthesising such species in order to gain insight into the principles of their structure and bonding, including the establishment of suitable spectroscopic methods for their detection (in particular by NMR methods). A second part should prove the usefulness of the knowledge gained in the biochemistry of silicon, that is, each newly recognised motif shall be tested on real biomolecules. Our strategy to synthesise the species of interest is to provide carbohydrate-based O-atom patterns that ensure chelation of silicon without any strain. According to DFT calculations, there is enough evidence that such structures should be obtainable.