Binding principles of silicic acid by carbohydrates

硅酸与碳水化合物的结合原理

• 批准号: 27665127
• 负责人: Professor Dr. Peter Klüfers
• 金额: --
• 依托单位: Lehrstuhl für Bioanorganische Chemie und Koordinationschemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/27665127?language=en
• 关键词: Binding; principles; silicic; acid; carbohydrates

Carbohydrates are suitable chelating ligands for silicon to establish hydrolytically stable Si¿O¿C bonds. In this field ¿hypervalent¿ silicon complexes (coordination number five and six) are stable in strongly alkaline solution but unstable under the conditions of a physiological pH value and therefore they should possess no relevance in the biochemistry of silicon. Thus it is the aim of this project to synthesise (hydrolytically stable) tetracoordinate carbohydrate-silicon compounds, Si(OR)4, representing novel Si1 building blocks for biomimetic production of silica derivatives as possible transport forms in biochemistry. One part deals with the recognition of rules and concepts for synthesising such species in order to gain insight into the principles of their structure and bonding, including the establishment of suitable spectroscopic methods for their detection (in particular by NMR methods). A second part should prove the usefulness of the knowledge gained in the biochemistry of silicon, that is, each newly recognised motif shall be tested on real biomolecules. Our strategy to synthesise the species of interest is to provide carbohydrate-based O-atom patterns that ensure chelation of silicon without any strain. According to DFT calculations, there is enough evidence that such structures should be obtainable.

碳水化合物是硅的合适的螯合配体，以建立水解稳定的Si¿O¿C键。在这个领域，高价硅配合物（配位5号和6号）在强碱性溶液中是稳定的，但在生理pH值的条件下是不稳定的，因此它们在硅的生物化学中应该没有相关性。因此，这个项目的目的是合成（水解稳定的）四配位碳水化合物硅，Si(OR)4，代表了硅衍生物作为生物化学中可能的运输形式的仿生生产的新型Si1构建块。其中一部分涉及合成这些物种的规则和概念的识别，以便深入了解它们的结构和键合原理，包括建立合适的光谱方法来检测它们（特别是通过核磁共振方法）。第二部分应该证明在硅生物化学中获得的知识的有用性，也就是说，每个新识别的基序应该在真实的生物分子上进行测试。我们合成感兴趣的物种的策略是提供基于碳水化合物的o原子模式，以确保硅的螯合没有任何张力。根据DFT计算，有足够的证据表明这种结构应该是可以得到的。