Phosphorus(V) Lewis acids for element-hydrogen and element-halogen bond activation - Application to reductions and to the synthesis of valuable organic building blocks

路易斯酸催化在有机化合物的转化中起着非常重要的作用。氟膦阳离子是一类新型的超强Lewis酸，其中处于氧化态V的磷原子是Lewis酸中心。我的研究将集中在氟膦化合物对硅-氢、硼-氢以及硼、硅和锡-卤键的催化应用。可以预见，用我的方法可以实现酮的无金属、不对称硅氢化和转移氢化的长期目标，并且可以克服目前无金属体系直接氢化的缺点。利用氟膦催化剂独特的反应性，进一步提出了一种催化工艺，可以在一步合成中获得一类全新的有机合成有价值的构件。

Lewis acid catalysis plays a prominent role in the transformation of organic compounds. Fluorophosphonium cations, where a phosphorus atom in the oxidation state +V is the Lewis acidic center, are a new class of exceptionally strong Lewis acids which will be investigated in this project.My research will focus on the catalytic application fluorophosphonium compounds for the activation of silicon-hydrogen, boron-hydrogen and boron-, silicon- and tin-halogen bonds. It is envisioned that with my methodology, the long-standing goal of metal-free, asymmetric hydrosilylation and transfer-hydrogenation of ketones can be achieved as well as drawbacks in direct hydrogenation with current metal-free systems can be overcome. Using the unique reactivity of fluorophosphonium catalysts it is further proposed that a catalytic process can be developed to access a whole new class of valuable building blocks for organic synthesis a single synthetic step.