Phosphorus(V) Lewis acids for element-hydrogen and element-halogen bond activation - Application to reductions and to the synthesis of valuable organic building blocks

路易斯酸催化在有机化合物的转化中起着重要的作用。氟磷离子，其中磷原子在氧化态+V是刘易斯酸中心，是一类新的特别强的刘易斯酸，将在本项目中进行研究。我的研究将集中在氟磷化合物在硅-氢、硼-氢和硼-、硅-和锡-卤素键活化中的催化应用。可以设想，通过我的方法，可以实现长期以来的无金属、不对称硅氢化和酮类转移氢化的目标，并可以克服当前无金属系统直接加氢的缺点。利用氟磷催化剂的独特反应活性，进一步提出可以开发一种催化过程，以获得一种全新的有机合成有价值的构建块。

Lewis acid catalysis plays a prominent role in the transformation of organic compounds. Fluorophosphonium cations, where a phosphorus atom in the oxidation state +V is the Lewis acidic center, are a new class of exceptionally strong Lewis acids which will be investigated in this project.My research will focus on the catalytic application fluorophosphonium compounds for the activation of silicon-hydrogen, boron-hydrogen and boron-, silicon- and tin-halogen bonds. It is envisioned that with my methodology, the long-standing goal of metal-free, asymmetric hydrosilylation and transfer-hydrogenation of ketones can be achieved as well as drawbacks in direct hydrogenation with current metal-free systems can be overcome. Using the unique reactivity of fluorophosphonium catalysts it is further proposed that a catalytic process can be developed to access a whole new class of valuable building blocks for organic synthesis a single synthetic step.