Phosphorus(V) Lewis acids for element-hydrogen and element-halogen bond activation - Application to reductions and to the synthesis of valuable organic building blocks

刘易斯酸催化在有机化合物转化反应中起着重要作用。氟磷鎓阳离子是一类新型的超强刘易斯酸，其中氧化态为+V的磷原子是刘易斯酸中心，本项目将研究氟磷鎓化合物在活化硅-氢、硼-氢、硼-卤键、硅-卤键和锡-卤键中的催化应用。据设想，与我的方法，可以实现酮的无金属，不对称氢化硅烷化和转移氢化的长期目标，以及在直接氢化与当前的无金属系统的缺点可以克服。利用氟膦催化剂的独特反应性，进一步提出可以开发一种催化方法，以在单个合成步骤中获得用于有机合成的全新类别的有价值的构建单元。

Lewis acid catalysis plays a prominent role in the transformation of organic compounds. Fluorophosphonium cations, where a phosphorus atom in the oxidation state +V is the Lewis acidic center, are a new class of exceptionally strong Lewis acids which will be investigated in this project.My research will focus on the catalytic application fluorophosphonium compounds for the activation of silicon-hydrogen, boron-hydrogen and boron-, silicon- and tin-halogen bonds. It is envisioned that with my methodology, the long-standing goal of metal-free, asymmetric hydrosilylation and transfer-hydrogenation of ketones can be achieved as well as drawbacks in direct hydrogenation with current metal-free systems can be overcome. Using the unique reactivity of fluorophosphonium catalysts it is further proposed that a catalytic process can be developed to access a whole new class of valuable building blocks for organic synthesis a single synthetic step.