Manipulation of Pro- and Anti-Inflammatory Cytokine Production and Dysregulated Resolution of Inflammation by Helicobacter pylori (A04)

幽门螺杆菌是人类持续感染和慢性炎症的典范，而高毒力菌株会被小鼠免疫系统迅速消除。我们的目标是了解人类和小鼠控制炎症持续或消退的调控过程，并详细探讨幽门螺杆菌感染过程中炎症体形成、促炎和抗炎细胞因子、细胞因子受体动力学和免疫调节因子的操纵。涉及劫持分子检查点的细菌因子将被确定。这种方法将识别新的关键致病决定因素，作为潜在的消炎新药靶点。

H. pylori is a paradigm of persistent infection and chronic inflammation in humans, while highly virulent strains are eliminated rapidly by the mouse immune system. We aim to understand regulatory processes in humans and mice that control the continuation or resolution of inflammation, and explore in detail the manipulation of inflammasome formation, pro- and anti-inflammatory cytokines, cytokine receptor dynamics and immune regulatory factors during H. pylori infection. The involved bacterial factors hijacking molecular checkpoints of resolution will be identified. This approach will identify novel key pathogenicity determinants serving as potential new drug targets for resolution of inflammation.