Manipulation of Pro- and Anti-Inflammatory Cytokine Production and Dysregulated Resolution of Inflammation by Helicobacter pylori (A04)

幽门螺杆菌对促炎和抗炎细胞因子产生的调控以及炎症调节失调的解决 (A04)

• 批准号: 277737674
• 金额: --
• 依托单位: Lehrstuhl für Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/277737674?language=en
• 关键词: Manipulation; Pro; Anti; Inflammatory; Cytokine

H. pylori is a paradigm of persistent infection and chronic inflammation in humans, while highly virulent strains are eliminated rapidly by the mouse immune system. We aim to understand regulatory processes in humans and mice that control the continuation or resolution of inflammation, and explore in detail the manipulation of inflammasome formation, pro- and anti-inflammatory cytokines, cytokine receptor dynamics and immune regulatory factors during H. pylori infection. The involved bacterial factors hijacking molecular checkpoints of resolution will be identified. This approach will identify novel key pathogenicity determinants serving as potential new drug targets for resolution of inflammation.

H.幽门螺杆菌是人类持续感染和慢性炎症的范例，而高毒力菌株可被小鼠免疫系统迅速消除。我们的目的是了解人类和小鼠控制炎症的持续或消退的调节过程，并详细探讨H.幽门感染将确定参与劫持分辨率的分子检查点的细菌因子。这种方法将确定新的关键致病性决定因素，作为潜在的新的药物靶点，以解决炎症。