Amplification of NET formation and neutrophil aggregation for the resolution of inflammation (C03)

C03项目（Herrmann/Hoffmann）利用了这一发现，即聚集的中性粒细胞胞外陷阱（NETs）通过降解细胞因子和趋化因子的能力有助于炎症的解决。根据第一个资助期获得的初步数据，C03将表征NETs中的糖苷酶活性，该活性调节免疫球蛋白功能，除了细胞因子/趋化因子的切割外，可能还负责NETs解决炎症。此外，将开发一种药理学方法，允许中性粒细胞扩增活性氧（ROS）的产生，从而形成聚集的NET，诱导炎症的消退。

Project C03 (Herrmann/Hoffmann) leverages on the finding that aggregated neutrophil extracellular traps (NETs) contribute to resolution of inflammation by their capacity to degrade cytokines and chemokines. Based on the preliminary data obtained during the first funding period C03 will characterize the glycosidase activity in NETs, which modulates immunoglobulin-function and, apart from cytokine/chemokine cleavage, is presumably responsible for the resolution of inflammation by NETs. Furthermore, a pharmacological approach will be developed that allows amplification of reactive oxygen species (ROS) production by neutrophils and, in consequence, the formation of aggregated NET that induce resolution of inflammation.