Amplification of NET formation and neutrophil aggregation for the resolution of inflammation (C03)

增强 NET 形成和中性粒细胞聚集以解决炎症 (C03)

• 批准号: 277745151
• 金额: --
• 依托单位: Klinik für Dermatologie, Allergologie und Venerologie (Hautklinik)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/277745151?language=en
• 关键词: Amplification; NET; formation; neutrophil; aggregation

Project C03 (Herrmann/Hoffmann) leverages on the finding that aggregated neutrophil extracellular traps (NETs) contribute to resolution of inflammation by their capacity to degrade cytokines and chemokines. Based on the preliminary data obtained during the first funding period C03 will characterize the glycosidase activity in NETs, which modulates immunoglobulin-function and, apart from cytokine/chemokine cleavage, is presumably responsible for the resolution of inflammation by NETs. Furthermore, a pharmacological approach will be developed that allows amplification of reactive oxygen species (ROS) production by neutrophils and, in consequence, the formation of aggregated NET that induce resolution of inflammation.

项目C 03（Herrmann/Hoffmann）利用了聚集的中性粒细胞胞外陷阱（NET）通过其降解细胞因子和趋化因子的能力有助于缓解炎症的发现。基于在第一个资助期内获得的初步数据，C 03将表征NET中的糖苷酶活性，其调节免疫球蛋白功能，并且除了细胞因子/趋化因子裂解外，推测还负责NET的炎症消退。此外，将开发一种药理学方法，允许中性粒细胞产生活性氧（ROS），从而形成聚集的NET，诱导炎症消退。