Dynamics of transcriptional complexes and interplay of the archaeal RNA polymerase with RNA processing proteins (A07)

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We plan to investigate the elongation phase of archaeal and eukaryotic transcription. We aim to i) delineate the structural (re-)organisation of the RNA polymerase I transcription machinery during the transition from the initiation to elongation phase at the single-molecule level and ii) to elucidate how transcription and co-transcriptional processes are orchestrated in Archaea with a special focus on the biochemical and structural characterisation of the coupling transcription and translation machinery and the role of Lsm-containing RNPs.