Thalamic processing of pain and putative control by cortical feedback (G01)

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The relationship between thalamic sensory processing, cortical feedback and pain perception is not clear, in particular between pathophysiological changes in thalamic activity patterns and the chronicity of pain. We will address thalamic pain processing and its dependency to cortical feedback circuits using electrophysiology, cell-type specific modulation of neuronal activity, and behavioural assays in awake, behaving mice. Understanding pathophysiological changes in thalamic function and regulation that are associated with the development of chronic pain will help us to establish a causal relationship between thalamic operational states and pain perception and will be important for the identification of potential targets for pain treatment.