Thalamic processing of pain and putative control by cortical feedback (G01)

丘脑对疼痛的处理和皮质反馈的假定控制（G01）

• 批准号: 278571578
• 金额: --
• 依托单位: Institut für Physiologie und Pathophysiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/278571578?language=en
• 关键词: Thalamic; processing; pain; putative; control

The relationship between thalamic sensory processing, cortical feedback and pain perception is not clear, in particular between pathophysiological changes in thalamic activity patterns and the chronicity of pain. We will address thalamic pain processing and its dependency to cortical feedback circuits using electrophysiology, cell-type specific modulation of neuronal activity, and behavioural assays in awake, behaving mice. Understanding pathophysiological changes in thalamic function and regulation that are associated with the development of chronic pain will help us to establish a causal relationship between thalamic operational states and pain perception and will be important for the identification of potential targets for pain treatment.

丘脑感觉处理、皮质反馈和疼痛感知之间的关系尚不清楚，特别是丘脑活动模式的病理生理变化与疼痛的慢性性之间的关系尚不清楚。我们将利用电生理学、神经元活动的细胞类型特异性调节以及清醒、行为小鼠的行为测定来解决丘脑疼痛处理及其对皮质反馈回路的依赖性。了解与慢性疼痛发展相关的丘脑功能和调节的病理生理变化将有助于我们建立丘脑操作状态和疼痛感知之间的因果关系，并且对于确定疼痛治疗的潜在目标非常重要。