THALAMIC MECHANISMS OF PAIN

丘脑疼痛机制

• 批准号: 2409729
• 负责人: JONATHAN O DOSTROVSKY
• 金额: $ 8.56万
• 依托单位: UNIVERSITY OF TORONTO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2409729
• 关键词: brain electrical activity; brain mapping; clinical research; electrostimulus; human subject; neural information processing; neurosurgery; pain; thalamus; wakefulness

DESCRIPTION: The overall goal of these studies is to elucidate the thalamic mechanisms underlying the perception of painful stimuli and chronic pain. These novel studies are made feasible by the unique opportunity afforded to us during functional stereotactic neurosurgery when we are able to record the activity of neurons and determine the effects of microstimulation in awake patients with movement disorders or chronic pain. The major aims of the project are to I: Demonstrate the existence of nociceptive neurons within human Vc (the ventrobasal complex; VB), characterize their responses, determine whether microstimulation at such sites gives rise to painful sensations and examine whether blocking the activity of the neurons in this region will result in alteration of pain perception II: Perform similar studies but for neurons located ventroposterior to Vc in a region termed Vcpc/VMpo. III. Perform similar studies as in I and II above but for neurons located in medial thalamus. IV: To analyze the incidence, locations and firing patterns of bursting cells (proposed to contribute to chronic pain) in medial and lateral thalamus and determine the effects of blocking their activity on chronic pain. These goals will be achieved by a combination of extracellular neurons recordings, microstimulation-evoked sensations and effects of temporary block of neuronal activity in awake patients. The proposed studies will test the hypotheses that Vc, Vcpc/VMpo, and medial thalamus are involved in mediating various aspects of the pain experience and that cells firing spontaneously in a bursting pattern may be related to chronic pain. The results of these novel and unique studies should considerably advance our understanding of the role of thalamus in both chronic and acute pain and could provide a radical new conceptual framework of thalamic pain mechanisms. Improved understanding of thalamic mechanisms of acute and chronic pain may lead to the development of new therapeutic approaches.

描述：这些研究的总体目标是阐明丘脑 疼痛刺激和慢性疼痛感知的机制。 这些新颖的研究因提供的独特机会而变得可行 当我们能够记录功能性立体定向神经外科手术时 神经元的活动并确定微刺激的效果 患有运动障碍或慢性疼痛的清醒患者。 主要目标 该项目的目的是：证明伤害性神经元的存在 在人类 Vc（腹基底复合体；VB）内，表征它们的反应， 确定这些部位的微刺激是否会引起疼痛 感觉并检查是否阻断了该神经元的活动 区域将导致疼痛感知的改变 II：执行类似的操作 研究但对于位于 Vc 腹后部的区域中的神经元 Vcpc/VMpo。 三． 进行与上述 I 和 II 类似的研究，但对于 神经元位于内侧丘脑。 IV：分析发病率， 破裂细胞的位置和放电模式（建议有助于 内侧和外侧丘脑的慢性疼痛）并确定 阻止他们对慢性疼痛的活动。 这些目标将通过 细胞外神经元记录、微刺激诱发的组合 清醒时暂时阻断神经元活动的感觉和影响 患者。 拟议的研究将检验 Vc、Vcpc/VMpo、 和内侧丘脑参与调节疼痛的各个方面 经验和细胞以爆发模式自发放电可能是 与慢性疼痛有关。 这些新颖独特的研究结果 应该大大增进我们对丘脑在 慢性和急性疼痛，可以提供一个全新的概念 丘脑疼痛机制的框架。 增进对丘脑的了解 急性和慢性疼痛的机制可能会导致新的治疗方法的开发 治疗方法。