Enlightening inhibitory neurotransmitter receptor organization and dynamics applying high end microscopy (B05)

GABAA和甘氨酸受体是中枢神经系统和大脑中快速突触抑制的主要媒介，因此对认知、行为和意识至关重要。在这里，我们将系统和全面地研究控制这些受体在神经元突触的数量和组织的分子机制。受体-蛋白质的相互作用将在体外进行探索，在细胞和组织材料中进行功能表征，并用高端显微镜以前所未有的分辨率进行可视化。因此，我们的研究将有助于破译最重要的受体相关蛋白的特定(病理)生理作用。

GABAA and glycine receptors are the major mediators of fast synaptic inhibition in the central nervous system and the brain, and thereby, critical for cognition, behavior, and consciousness. Here, we will systematically and comprehensively study the molecular mechanisms that control the numbers and the organization of these receptors at neuronal synapses. Receptor-protein interactions will be explored in vitro, functionally characterized in cells and in tissue material and visualized with high-end microscopy in unpreceded resolution. Thereby, our study shall help to decipher the specific (patho)physiological action of the most important receptor-associated proteins.