Does energy turnover after short-term nutritional recovery predict subsequent weight coursein patients with anorexia nervosa?A multicenter pilot study

神经性厌食症（AN）患者将体重增加描述为一个巨大的挑战。在成功的住院患者营养康复后，许多患者在出院后经历了新的体重减轻。除了持续对身体不满等心理因素外，生物障碍似乎使恢复和维持健康的正常体重变得复杂。高能量周转率可能对体重产生负面影响。在我们的多中心试点研究中，我们旨在使用同位素稀释法评估6名成人和4名青少年AN患者住院治疗后3-6周的总每日能量消耗（TDEE）。此外，我们计划对TDEE的决定因素（an亚型静息能量消耗、体力活动、能量摄入、身体组成）进行探索性分析，并在出院后6个月对体重进行随访。如果我们的初步研究产生了有希望的结果，我们将使用获得的数据进行资助申请，涉及更多的参与者和健康对照，在纵向设计中调查TDEE改变的临床相关性和潜在的生物学机制。

Patients with anorexia nervosa (AN) describe weight gain as a big challenge. After successful inpatient nutritional rehabilitation, many patients experience renewed weight loss following discharge. Next to psychological factors such as persisting body dissatisfaction, biological barriers seem to complicate recovery and maintenance of a healthy normal weight. A high energy turnover could have a negative impact on weight course. In our multicenter pilot study we aim to assess total daily energy expenditure (TDEE) using isotope dilution in 6 adult and 4 adolescent AN patients 3-6 weeks after admission to inpatient treatment. In addition we plan an explorative analysis of determinants of TDEE (AN subtype resting energy expenditure, physical activity, energy intake, body composition), as well as a follow-up of body weight 6 months after discharge. In case our pilot study yields promising results, we will use the acquired data for a grant proposal involving a higher number of participants as well as healthy controls, to investigate clinical relevance and underlying biological mechanisms of alterations in TDEE in a longitudinal design.