Functional characterization of Rasal1 in the signal transduction of plexins

Rasal1 在丛蛋白信号转导中的功能表征

• 批准号: 282067330
• 负责人: Professor Dr. Thomas Worzfeld
• 金额: --
• 依托单位: Pharmakologisches Institut
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/282067330?language=en
• 关键词: Functional; characterization; Rasal1; signal; transduction

Plexins comprise a family of transmembrane proteins, which serve as receptors for semaphorins. They play decisive roles in a multitude of physiological and pathophysiological processes, e.g. in the immune system, the bone system and in cancer. The signal transduction pathways of plexins remain poorly understood. In particular, the molecular mechanism through which plexins regulate the activity of Ras GTPases is largely unclear. The aim of this proposal is to characterize the role of the RasGAP protein Rasal1 for the signal transduction of plexins, and to analyze its functional relevance in vitro and in vivo in mice.

丛蛋白包括一个跨膜蛋白家族，作为信号蛋白的受体。它们在许多生理和病理生理过程中起着决定性作用，例如在免疫系统、骨骼系统和癌症中。神经丛蛋白的信号转导途径仍然知之甚少。特别是，丛蛋白调控Ras GTPases活性的分子机制在很大程度上尚不清楚。本研究的目的是表征RasGAP蛋白Rasal1在丛蛋白信号转导中的作用，并分析其在小鼠体内和体外的功能相关性。