Targeting selective autophagy in acute myeloid leukemia (E08 (C05))

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Autophagic flux is significantly increased in primary acute myeloid leukemia (AML) samples compared to normal hematopoietic stem cells. Based on our previous data, we now aim to understand the molecular mechanisms governing mitophagy in AML, and we aim to identify kinases and kinase inhibitors regulating mitophagy. Furthermore, we plan to study the role of MST kinases in regulating autophagy in AML and to develop highly selective MST1/2 and MST3/4 inhibitors (so called chemical probes), and to assess their potential for new treatment strategies in AML.