Targeting selective autophagy in acute myeloid leukemia (E08 (C05))

靶向急性髓系白血病的选择性自噬 (E08 (C05))

• 批准号: 283395582
• 金额: --
• 依托单位: Institut für Pharmazeutische Chemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/283395582?language=en
• 关键词: Targeting; selective; autophagy; acute; myeloid

Autophagic flux is significantly increased in primary acute myeloid leukemia (AML) samples compared to normal hematopoietic stem cells. Based on our previous data, we now aim to understand the molecular mechanisms governing mitophagy in AML, and we aim to identify kinases and kinase inhibitors regulating mitophagy. Furthermore, we plan to study the role of MST kinases in regulating autophagy in AML and to develop highly selective MST1/2 and MST3/4 inhibitors (so called chemical probes), and to assess their potential for new treatment strategies in AML.

与正常的造血干细胞相比，原发急性髓系白血病(AML)样本的自噬流量显著增加。基于我们以前的数据，我们现在的目标是了解AML中控制有丝分裂的分子机制，我们的目标是识别调节有丝分裂的激酶和激酶抑制剂。此外，我们计划研究MST激酶在调节AML自噬中的作用，开发高选择性的MST1/2和MST3/4抑制剂(所谓的化学探针)，并评估它们在AML新治疗策略中的潜力。