Identifying the mechanisms through which calcineurin regulates proportional growth control.
确定钙调神经磷酸酶调节比例生长控制的机制。
基本信息
- 批准号:283635409
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2015
- 资助国家:德国
- 起止时间:2014-12-31 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
All organisms grow organs and appendages to specific proportions in relation to their bodies, and those animals that regenerate them do so to the exact same dimensions as the lost original structures. The coordinated growth of organs and appendages during development and regeneration involves switching between growth rates that are disproportional to the body (allomentric) and growth rates that are proportional the body (isometric). While many aspects of the cell biology, hormone, growth factor and cell cycle regulation contribute to the cell proliferation associated with tissue growth are known, it remains unclear how these mechanisms are coordinated to produce proportional growth of organs and appendages relation to the body. My group discovered that inhibition of the calcium-regulated phosphatase calcineurin during the regeneration of zebrafish fins causes their loss of proportional growth control and that calcineurin inhibition in unamputated fins switched their isometric growth to allometric growth. While it is known that there are body-wide and local regulators of growth control, it is not known how these are regulated or integrated to control proportional growth of multi-tissue structures. Therefore, the goal of my Eigene Stelle (Temporary PI) proposal is to define how the calcium-regulated phosphatase calcineurin is integrated into the cell biology and molecular mechanisms that determine when tissue progenitor cells are to grow and to stop growing to maintain the proportional relationship to the body. To achieve this goal, I will determine: 1) which cell(s) mediates calcineurin-regulated of proportional growth; 2) what downstream molecular mechanisms mediate calcineurin-regulated proportional growth; 3) which molecular mechanisms (both Ca2+-mediated and Ca2+-independent) are regulating calcineurin to regulate proportional growth.
所有生物体都会按照与身体相关的特定比例生长器官和附属物,而那些再生它们的动物的尺寸与失去的原始结构完全相同。器官和附属物在发育和再生过程中的协调生长涉及在与身体不成比例的生长速率(异体生长)和与身体成比例的生长速率(等长生长)之间进行切换。虽然已知细胞生物学、激素、生长因子和细胞周期调节的许多方面有助于与组织生长相关的细胞增殖,但仍不清楚这些机制如何协调以产生与身体相关的器官和附属物的比例生长。我的小组发现,在斑马鱼鳍再生过程中抑制钙调节磷酸酶钙调神经磷酸酶会导致其失去比例生长控制,并且未截肢鳍中的钙调神经磷酸酶抑制将其等长生长转变为异速生长。虽然已知存在生长控制的全身和局部调节器,但尚不清楚如何调节或整合这些调节器以控制多组织结构的比例生长。因此,我的 Eigene Stelle(临时 PI)提案的目标是定义钙调节磷酸酶钙调磷酸酶如何整合到细胞生物学和分子机制中,从而确定组织祖细胞何时生长和停止生长以维持与身体的比例关系。为了实现这一目标,我将确定:1)哪些细胞介导钙调神经磷酸酶调节的比例生长; 2)哪些下游分子机制介导钙调神经磷酸酶调节的比例生长; 3) 哪些分子机制(Ca2+介导的和Ca2+非依赖性的)正在调节钙调磷酸酶以调节比例生长。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity
尽管 CaMKII 活性过度,但抑制物 1 的慢性缺失会降低心脏 RyR2 磷酸化
- DOI:10.1007/s00210-017-1376-1
- 发表时间:2017
- 期刊:
- 影响因子:0
- 作者:Neef S ;Brammen CAA;Wittköpper K;Heijman Jr;Antos CL;Otte C;Seitz T;Dewenter M;Saadatmand AR;Meyer-Roxlau S;Vettel C;Weber S;Backs J;Hasenfuss G;Dobrev D;Maier LS;El-Armouche A
- 通讯作者:El-Armouche A
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dr. Christopher Antos其他文献
Dr. Christopher Antos的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Dr. Christopher Antos', 18)}}的其他基金
Examining the mechanism of the gene simplet (smp) in nerve-dependent appendage regeneration of the zebrafish
研究简单基因(smp)在斑马鱼神经依赖性附肢再生中的机制
- 批准号:
157311488 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Research Grants
相似国自然基金
Exploring the Intrinsic Mechanisms of CEO Turnover and Market
- 批准号:
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国学者研究基金
Exploring the Intrinsic Mechanisms of CEO Turnover and Market Reaction: An Explanation Based on Information Asymmetry
- 批准号:W2433169
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国学者研究基金项目
Erk1/2/CREB/BDNF通路在CSF1R相关性白质脑病致病机制中的作用研究
- 批准号:82371255
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
Foxc2介导Syap1/Akt信号通路调控破骨/成骨细胞分化促进颞下颌关节骨关节炎的机制研究
- 批准号:82370979
- 批准年份:2023
- 资助金额:48.00 万元
- 项目类别:面上项目
MYRF/SLC7A11调控施万细胞铁死亡在三叉神经痛脱髓鞘病变中的作用和分子机制研究
- 批准号:82370981
- 批准年份:2023
- 资助金额:48.00 万元
- 项目类别:面上项目
Idh3a作为线粒体代谢—表观遗传检查点调控产热脂肪功能的机制研究
- 批准号:82370851
- 批准年份:2023
- 资助金额:48.00 万元
- 项目类别:面上项目
用于小尺寸管道高分辨成像荧光聚合物点的构建、成像机制及应用研究
- 批准号:82372015
- 批准年份:2023
- 资助金额:48.00 万元
- 项目类别:面上项目
小脑浦肯野细胞突触异常在特发性震颤中的作用机制及靶向干预研究
- 批准号:82371248
- 批准年份:2023
- 资助金额:47.00 万元
- 项目类别:面上项目
声致离子电流促进小胶质细胞M2极化阻断再生神经瘢痕退变免疫机制
- 批准号:82371973
- 批准年份:2023
- 资助金额:48.00 万元
- 项目类别:面上项目
GREB1突变介导雌激素受体信号通路导致深部浸润型子宫内膜异位症的分子遗传机制研究
- 批准号:82371652
- 批准年份:2023
- 资助金额:45.00 万元
- 项目类别:面上项目
相似海外基金
NSF Postdoctoral Fellowship in Biology: Identifying Mechanisms of Plant Symbiosis Control Through Virus Induced Mutant Stacking (VIMS)
NSF 生物学博士后奖学金:通过病毒诱导突变体堆积 (VIMS) 识别植物共生控制机制
- 批准号:
2305688 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Fellowship Award
Alcohol and "Heat of the Moment" Sexual Decision Making among MSM: Identifying Mechanisms of Sexual Risk and Promoting Behavior Change Through Brief Intervention
酒精与 MSM 中“一时冲动”的性决策:识别性风险机制并通过简短干预促进行为改变
- 批准号:
10684336 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Alcohol and "Heat of the Moment" Sexual Decision Making among MSM: Identifying Mechanisms of Sexual Risk and Promoting Behavior Change Through Brief Intervention
酒精与 MSM 中“一时冲动”的性决策:识别性风险机制并通过简短干预促进行为改变
- 批准号:
10541644 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Identifying selective visual attention mechanisms through high-dimensional analysis.
通过高维分析识别选择性视觉注意机制。
- 批准号:
9127978 - 财政年份:2015
- 资助金额:
-- - 项目类别:
IMPROVING CHILDREN’S WELL-BEING: IDENTIFYING MECHANISMS AND TIMING OF FAMILY STRENGTHENING PROGRAMS FOR LOW-INCOME FAMILIES THROUGH DIFFERENTIAL EQUATION MODELING
改善儿童福祉:通过微分方程模型确定低收入家庭家庭强化计划的机制和时机
- 批准号:
100090 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Identifying topiramate's therapeutic mechanisms through motivational salience
通过动机显着性识别托吡酯的治疗机制
- 批准号:
8913104 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Identifying topiramate's therapeutic mechanisms through motivational salience
通过动机显着性识别托吡酯的治疗机制
- 批准号:
8530205 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Identifying topiramate's therapeutic mechanisms through motivational salience
通过动机显着性识别托吡酯的治疗机制
- 批准号:
8399466 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Identifying topiramate's therapeutic mechanisms through motivational salience
通过动机显着性识别托吡酯的治疗机制
- 批准号:
9130135 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Identifying topiramate's therapeutic mechanisms through motivational salience
通过动机显着性识别托吡酯的治疗机制
- 批准号:
8713971 - 财政年份:2012
- 资助金额:
-- - 项目类别: