Genomic and functional analysis of monocyte-derived cells and microglia during experimental autoimmune encephalomyelitis

实验性自身免疫性脑脊髓炎期间单核细胞衍生细胞和小胶质细胞的基因组和功能分析

• 批准号: 287037189
• 负责人: Professor Dr. Alexander Mildner, Ph.D.
• 金额: --
• 依托单位: Forschungsgruppe Zelldifferenzierung und Tumorigenese
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/287037189?language=en
• 关键词: Genomic; functional; analysis; monocyte; derived

Myeloid cells such as monocytes as well as microglia play a potentially pathological role in the central nervous system during the development of multiple sclerosis (MS) or its animal model experimental autoimmune encephalomyelitis (EAE), but how they contribute to disease progression is still unclear. Within this research grant we aim to understand the temporal and molecular changes of monocytes and microglia during EAE development in mice. We hope to identify a characteristic functional signature in monocytes or microglia, which can be used to specifically interfere or promote certain myeloid differentiation programs to open the way for new therapeutical options to treat MS.

在多发性硬化（MS）及其动物模型实验性自身免疫性脑脊髓炎（EAE）的发展过程中，髓样细胞如单核细胞和小胶质细胞在中枢神经系统中发挥着潜在的病理作用，但它们如何促进疾病进展仍不清楚。在这项研究资助中，我们的目标是了解小鼠EAE发展过程中单核细胞和小胶质细胞的时间和分子变化。 我们希望在单核细胞或小胶质细胞中识别出一种特征性的功能特征，它可以用于特异性干扰或促进某些骨髓分化程序，为治疗MS的新治疗方案开辟道路。