Microglial lipid metabolism during physiological and pathological conditions

生理和病理条件下的小胶质细胞脂质代谢

• 批准号: 500297100
• 负责人: Professor Dr. Alexander Mildner, Ph.D.
• 金额: --
• 依托单位: MediCity Research Laboratory
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/500297100?language=en
• 关键词: Microglial; lipid; metabolism; during; physiological

An important task of microglia is the phagocytosis and the breakdown of dead cells and extracellularly deposited proteins and lipids. The presence of extracellular deposits can increase under pathological conditions and aging processes. Due to the large number of different CNS cell types, which in turn all express a specific repertoire of proteins, microglia must be able to adapt their metabolism and catabolism to the phagocytosed material in order to avoid an intracellular accumulation of lipids, which in turn leads to the activation of microglia. This is the case, for example, during neurodegenerative diseases such as Alzheimer's disease, where activated microglia can contribute to a worsening of the clinical disease course.In this research project we want to investigate whether and how the lipid metabolism in microglia can be used to increase lipid catabolism and thereby reduce the activation of microglia. The results can help to identify new therapeutic intervention options that can be used, for example, in Alzheimer's disease.

小胶质细胞的一个重要任务是吞噬和分解死细胞和细胞外沉积的蛋白质和脂质。在病理条件和衰老过程中，细胞外沉积物的存在可能会增加。由于大量不同的CNS细胞类型，这些细胞类型又都表达特定的蛋白质库，小胶质细胞必须能够使其代谢和催化剂适应吞噬的物质，以避免脂质的细胞内积累，这又导致小胶质细胞的活化。例如，在阿尔茨海默氏病等神经退行性疾病中，激活的小胶质细胞会导致临床疾病进程的恶化。本研究项目旨在探讨小胶质细胞中的脂质代谢是否以及如何用于增加脂质代谢，从而减少小胶质细胞的激活。这些结果可以帮助确定新的治疗干预方案，例如可以用于阿尔茨海默病。