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Mechanisms and impact of NMDA-receptor signaling during sensory processing in an echo-locating circuit

回声定位电路感觉处理过程中 NMDA 受体信号传导的机制和影响

基本信息

批准号：
289142182
负责人：
Professor Dr. Felix Felmy
金额：
--
依托单位：
Institut für Zoologie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2015
资助国家：
德国
起止时间：
2014-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/289142182?language=en
关键词：
Mechanisms impact NMDA receptor signaling

项目摘要

The role of NMDA-receptors in neuronal plasticity is well established. However, their role in intracellular voltage-signaling and sensory processing is less well characterized, yet they are implicated in amplifying action potential firing rates. To understand the cellular basis for this NMDA dependent amplification of firing rate, its influence on sensory information processing we will perform in vivo and in vitro recordings of neurons in the dorsal nucleus of the lateral lemniscus (DNLL) - an auditory brainstem structure important for binaural hearing. We will determine the synaptic interactions of excitation and inhibition with NMDA-receptor conductances to understand their contributions to intracellular voltage-signaling in vitro. Using in vivo pharmacology we will answer what impact NMDA receptors have on sound driven firing rates. Thereby, the DNLL serves on the one hand as a read out nucleus where the impact of NMDA-receptors on relaying binaural information will be quantified. On the other hand we will assay in vivo the direct binaural interactions at the level of the DNLL to understand the influence of NMDA-receptors on interactions between inhibition and excitation. We hypothesize that these interactions might be crucial in terminating a long lasting inhibition that is regarded as a cellular correlate for the suppression of sound sources during echoes.

NMDA受体在神经元可塑性中的作用已得到充分证实。然而，它们在细胞内电压信号传导和感觉处理中的作用不太清楚，但它们涉及放大动作电位放电率。为了了解这种NMDA依赖的放电率放大的细胞基础，其对感觉信息处理的影响，我们将在体内和体外记录外侧丘系（DNLL）背核中的神经元-听觉脑干结构对双耳听力很重要。我们将确定兴奋和抑制与NMDA受体电导的突触相互作用，以了解它们对体外细胞内电压信号的贡献。使用体内药理学，我们将回答NMDA受体对声音驱动放电率的影响。因此，DNLL一方面用作读出核，其中NMDA受体对中继双耳信息的影响将被量化。另一方面，我们将在体内测定DNLL水平上的直接双耳相互作用，以了解NMDA受体对抑制和兴奋之间相互作用的影响。我们假设，这些相互作用可能是至关重要的，在终止一个长期持续的抑制，被认为是一个细胞相关的声源在回声的抑制。