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Development and optimization of a membrane-inlet-photoionization mass spectrometer for real-time analysis of (poly)aromatic and halogenated compounds in aquatic systems

开发和优化膜入口光电离质谱仪，用于实时分析水生系统中的（多）芳香族和卤代化合物

基本信息

批准号：
289642123
负责人：
Professor Dr. Ralf Zimmermann
金额：
--
依托单位：
Leibniz-Institut für Ostseeforschung Warnemünde (IOW)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2016
资助国家：
德国
起止时间：
2015-12-31 至 2019-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/289642123?language=en
关键词：
Development optimization membrane inlet photoionization

项目摘要

Fast and sensitive analysis of (poly)aromatic and halogenated compounds is of high importance due to their environmental behavior, high biological activity and toxicity. Very low concentrations of such compounds in marine environments make their detection and monitoring difficult. Therefore, currently laborious enrichment techniques (such as purge-and-trap and extraction) are applied. A promising alternative in this regard is resonance-enhanced multiphoton ionization (REMPI) coupled to time-of-flight mass spectrometry. As a result of the specific ionization scheme REMPI provides selective and sensitive detection of (poly)aromatic species. A challenge for the utilization of REMPI in aquatic systems is the transfer of dissolved analytes to the gas phase. An auspicious approach constitutes the application of membrane inlets. For membrane inlet mass spectrometry (MIMS) analytes are transported selectively from the liquid phase through a semipermeable membrane into the vacuum of the mass spectrometer, losing the matrix in the process. Advantages are enrichment of the analytes on the membrane surface and a considerable reduction of analysis time. In the framework of the proposed project a REMPI-MIMS system for real-time analysis of (poly)aromatic and halogenated compounds in sea water will be developed and optimized for employment on a research ship cruise in the Baltic Sea. Besides planning and construction of a membrane inlet the development and characterization of a robust coupling of the inlet to a mass spectrometer is put forward. By doing this, improvement of limits of detection takes center stage. Furthermore several parameters such as temperature and salinity will be investigated with respect to the performance of the new analytical system. Validation of the system will be cross-checked by GC-MS measurements.

由于（多）芳香族化合物和卤代化合物的环境行为、高生物活性和毒性，对其进行快速、灵敏的分析非常重要。海洋环境中此类化合物的浓度非常低，因此检测和监测变得困难。因此，目前应用了费力的富集技术（例如吹扫捕集和萃取）。在这方面，一个有前途的替代方案是与飞行时间质谱联用的共振增强多光子电离（REMPI）。由于采用特定的电离方案，REMPI 可以选择性且灵敏地检测（多）芳香族物质。在水生系统中使用 REMPI 的一个挑战是将溶解的分析物转移到气相。一种吉祥的方法是应用膜入口。对于膜入口质谱 (MIMS)，分析物选择性地从液相通过半透膜转移到质谱仪的真空中，在此过程中会损失基质。优点是膜表面上分析物的富集和分析时间的显着减少。在拟议项目的框架内，将开发并优化用于实时分析海水中（多）芳香族化合物和卤代化合物的 REMPI-MIMS 系统，以便在波罗的海的一艘研究船巡航中使用。除了膜入口的规划和构造之外，还提出了入口与质谱仪的稳健耦合的开发和表征。通过这样做，检测极限的改进成为焦点。此外，还将根据新分析系统的性能研究温度和盐度等几个参数。系统的验证将通过 GC-MS 测量进行交叉检查。