Identifying and targeting escape mechanisms in AML using multispecific antibody derivatives (A10)

异基因干细胞移植治疗AML是由T细胞介导的，但其高死亡率阻碍了AML的治疗。我们发现，T细胞功能是通过AML及其肿瘤微环境(TME)的表型和功能的渐进性变化来调节的。我们的目标是揭示T细胞反应的变化，开发多特异性抗体衍生物(MSAD)，专为干扰AML亚型特定基因和表型的免疫检查点分子而定制。

Treatment of AML by allogeneic stem cell transplantation is mediated by T cells but is hampered by a high mortality rate. We find that T-cell function is modulated through progressively evolving changes in phenotype and function of AML and its tumor microen¬vironment (TME). Our goal is to unravel changes in T-cell responses and develop multi-specific antibody derivatives (msADs), tailored to interfere with immune checkpoint molecules in specific geno- and phenotype of AML subtypes.