Functional genome analysis of genetic and epigenetic evolution of hematopoetic neoplasms by next generation sequencing (Z02)

通过二代测序对造血系统肿瘤的遗传和表观遗传进化进行功能基因组分析（Z02）

• 批准号: 290365253
• 金额: --
• 依托单位: Laboratorium für funktionale Genomanalyse (LAFUGA)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/290365253?language=en
• 关键词: Functional; genome; analysis; genetic; epigenetic

High throughput sequencing of short DNA fragments is a powerful tool to study hematopoietic neoplasms. Sequencing with Nanopores also interrogates long native DNA and RNA and thus captures structural variations and modified nucleotides. We will provide our knowledge to perform and evaluate both short and long read high throughput sequencing. Furthermore, we will operate and expand the central IT platform of this CRC for the documentation, comparative analysis of results and visualization of various findings.

短DNA片段的高通量测序是研究造血肿瘤的有力工具。利用纳米孔进行测序还可以询问长链天然DNA和RNA，从而捕获结构变异和修饰的核苷酸。我们将提供我们的知识来执行和评估短读和长读高通量测序。此外，我们亦会运作及扩展该中心的中央资讯科技平台，以编制文件、比较分析研究结果，以及将各项研究结果可视化。