KFO 167: Regulation of Apoptosis and its Deregulation in Disease

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Cell death has long been considered as an accident in the tissue induced by nutrient and oxygen deprivation, infections or poisons. However, during the last two decades it has become clear that cell death occurs through a regulated programme, which is present in all cells. This programme is induced e.g. through hypoxia, damage to DNA or binding of death mediating ligands to so-called death receptors on the surface of cells. The death signal is translated into genetic programmes uniformly present in all cells.