局所進行胃癌に対する術前補助化学療法の個別化を目指したバイオマーカーの検索

寻找局部晚期胃癌个体化新辅助化疗的生物标志物

• 批准号: 21K08688
• 负责人: 青山 徹
• 金额: $ 2.66万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K08688/
• 关键词: 胃癌; 化学療法; 予後因子; バイオマーカー; 食道胃接合部癌

胃癌における各種バイオマーカーの検索を行った．検討の結果，血液検査データを用いた各種炎症栄養マーカーが胃癌における予後因子としての役割が明らになった．具体的には，Systemic Inflammation Score (SIS)やControlling Nutritional Status (CONUT) などが有望なバイオマーカである可能性が示唆された．SISは，リンパ球単球比率及び血清アルブミン値から算出し、蛋白合成能及び免疫能を反映している．検討の結果，SISの1をカットとして，SIS high群とSIS score low群の2群に分けると5年の生存率はそれぞれ，SIS　low群で78.9%、SIS high群で55.6%であった．さらに，全生存に関する単変量多変量解析からSISは独立した予後因子であった．またCONUT scoreは，アルブミン値、総コレステロール値、リンパ球数から算出し，蛋白合成能・脂質代謝能・免疫能を反映している．検討の結果，CONUT score 2をカットオフとしてCONUT score high群とCONUT score low群の2群に分けると3年及び5年の生存率はそれぞれ，CONUTlow群で93.6% と88.6%、CONUT high群で82.7% と73.6%であった．さらに，全生存に関する単変量多変量解析からCONUT scoreは独立した予後因子であった．

All kinds of cancer products were tested for gastric cancer. The results showed that the blood test was used to predict the risk of gastric cancer. The Systemic Inflammation Score (SIS) Controlling Nutritional Status (CONUT) test is expected to show the possibility of infection. SIS. The percentage of globulin and serum albumin synthesis energy and immune energy were calculated. The results showed that SIS1, SIS high, SIS score low, 2, 5-year survival rates were significantly different, 78.9% in SIS low group, 55.6% in SIS high group. Multi-dose analysis of the whole survival cycle, SIS, independent prediction of the following factors, the number of balls, the number of balls, protein synthesis, protein synthesis, immune response, protein synthesis, lipid metabolism, immune response, protein synthesis, protein synthesis, immune response, protein synthesis, immune response, immune response, protein synthesis, immune response, protein synthesis, immune response, immune response, protein synthesis, immune response, protein synthesis, immune response, immune response, protein synthesis, immune response, immune response, protein synthesis, immune response The 3-year and 5-year survival rates of CONUT score 2, CONUTlow, CONUT high and CONUT high were 93.6%, 88.6%, 82.7%, 73.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%, 82.7%, 73.6%, 88.6%, 88.6%, 88.6%, 88.6%, 88.6%,

项目成果

The Clinical Impact of the Tumor Stroma Ratio in Gastrointestinal Cancer Treatment

• DOI: 10.21873/anticanres.16346
• 发表时间: 2023-04
• 期刊: AntiCancer Research
• 影响因子: 2
• 作者: T. Aoyama;I. Hashimoto;T. Oshima

Safety and Feasibility of Gastrectomy for Gastric Cancer in Patients Receiving Antiplatelet and/or Anticoagulation Treatment

接受抗血小板和/或抗凝治疗的胃癌患者行胃切除术的安全性和可行性

• DOI: 10.21873/anticanres.15375
• 发表时间: 2021
• 期刊: Anticancer Research
• 影响因子: 2
• 作者: AOYAMA TORU;NAKAZONO MASATO;SEGAMI KENKI;NAGASAWA SHINSUKE;HARA KENTARO;TAMAGAWA HIROSHI;KOMORI KEISUKE;SUEMATSU HIDEAKI;MAEZAWA YUKIO;KANO KAZUKI;HASHIMOTO ITARU;YAMADA TAKAONOBU;SATO TSUTOMU;NUMATA MASAKATSU;YUKAWA NORIO;OGATA TAKASHI;RINO YASUSHI;OSHIM
• 通讯作者: OSHIM

Clinical Course of Vitamin B12 Deficiency and Associated Risk Factors in Patients After Total Gastrectomy for Gastric Cancer

• DOI: 10.21873/anticanres.16207
• 发表时间: 2023-02-01
• 期刊: ANTICANCER RESEARCH
• 影响因子: 2
• 作者: Aoyama, Toru;Hara, Kentaro;Rino, Yasushi
• 通讯作者: Rino, Yasushi

Prognostic Nutritional Index as a Predictor of Prognosis in Postoperative Patients With Gastric Cancer

预后营养指数作为胃癌术后患者预后的预测因子

• DOI: 10.21873/invivo.13207
• 发表时间: 2023
• 期刊: In Vivo
• 影响因子: 2.3
• 作者: ISHIGURO TETSUSHI;AOYAMA TORU;JU MIHWA;KAZAMA KEISUKE;FUKUDA MOMOKO;KANAI HARUKA;SAWAZAKI SHO;TAMAGAWA HIROSHI;TAMAGAWA AYAKO;CHO HARUHIKO;HARA KENTARO;NUMATA MASAKATSU;HASHIMOTO ITARU;MAEZAWA YUKIO;SEGAMI KENKI;OSHIMA TAKASHI;SAITO AYA;YUKAWA NORIO;RINO
• 通讯作者: RINO

The Clinical Influence of the CONUT Score on Survival of Patients With Gastric Cancer Receiving Curative Treatment

• DOI: 10.21873/invivo.12784
• 发表时间: 2022-03-01
• 期刊: IN VIVO
• 影响因子: 2.3
• 作者: Aoyama, Toru;Komori, Keisuke;Oshima, Takashi
• 通讯作者: Oshima, Takashi