Real-time precision functional network mapping of the human brain for neurosurgical applications

用于神经外科应用的人脑实时精确功能网络映射

• 批准号: 21K09149
• 负责人: Bagarinao E.
• 金额: $ 2.66万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K09149/
• 关键词: precision mapping; functional connectivity; real-time fMRI; essential tremor; resting state fMRI; human connectome; neurosurgery

For the FY2022, we have scanned 10 more healthy volunteers, completing the MRI scans of all 20 healthy controls. All participants underwent two imaging sessions, about one month apart. Acquired MRI data includes structural T1 MRI data, an hour of resting state functional MRI data, and diffusion-weighted MRI data. Additionally, we have also acquired the MRI data from patients with essential tremor. Preliminary analysis of the acquired datasets from healthy controls have shown that the reliability of the whole-brain FCOR map exhibited an initial rapid increase as more volumes are incorporated into the analysis. With more volumes added, the reliability measure later plateaus suggesting an upper limit to the reliability as well as an optimal number of volumes to achieve this limit. We have also started the analysis of the data from patients with essential tremor. This will be completed in FY2023.

于2022财政年度，我们扫描了另外10名健康志愿者，完成了所有20名健康对照者的MRI扫描。所有参与者都接受了两次成像，间隔约一个月。采集的MRI数据包括结构T1 MRI数据、一小时静息状态功能MRI数据和弥散加权MRI数据。此外，我们还获得了原发性震颤患者的MRI数据。对从健康对照组获得的数据集的初步分析表明，随着更多体积被纳入分析，全脑FCOR图的可靠性表现出初始快速增加。随着更多体积的添加，可靠性测量稍后达到平台，这表明可靠性的上限以及达到该限制的最佳体积数量。我们还开始分析原发性震颤患者的数据。此将于二零二三年财政年度完成。

项目成果

Reserve and Maintenance in the Aging Brain: A Longitudinal Study of Healthy Older Adults

• DOI: 10.1523/eneuro.0455-21.2022
• 发表时间: 2022-01-01
• 期刊: ENEURO
• 影响因子: 3.4
• 作者: Bagarinao, Epifanio;Watanabe, Hirohisa;Sobue, Gen
• 通讯作者: Sobue, Gen

Reproducibility of functional connectivity metrics estimated from resting-state functional MRI with differences in days, coils, and global signal regression

• DOI: 10.1007/s12194-022-00670-6
• 发表时间: 2022-08-12
• 期刊: RADIOLOGICAL PHYSICS AND TECHNOLOGY
• 影响因子: 1.6
• 作者: Kato，Sanae;Bagarinao，Epifanio;Sobue，Gen
• 通讯作者: Sobue，Gen

Brain imaging: From functional mapping to mind reading

脑成像：从功能映射到读心术

• 发表时间: 2021
• 作者: 新田雅之;村垣善浩ら;Epifanio Bagarinao
• 通讯作者: Epifanio Bagarinao

Impairments of connector hubs in brain disorders

脑部疾病中连接器枢纽的损伤

• 发表时间: 2023
• 作者: 武藤淳;峯裕;西山悠也;村山和宏;安達一英;長谷川光広;廣瀬雄一;山田茂樹;Epifanio Bagarinao
• 通讯作者: Epifanio Bagarinao

Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor

• DOI: 10.3171/2022.5.jns22411
• 发表时间: 2022-02-01
• 期刊: JOURNAL OF NEUROSURGERY
• 影响因子: 4.1
• 作者: Kato, Sachiko;Maesawa, Satoshi;Sobue, Gen
• 通讯作者: Sobue, Gen