Tissue Engineering the Meniscus: Combining Novel Biomimetic Hybrid Scaffolds with Adult Stem Cells

半月板组织工程：新型仿生混合支架与成体干细胞相结合

• 批准号: DP0774348
• 负责人: Prof Julie Campbell
• 金额: $ 29.83万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0774348
• 关键词: Tissue; Engineering; Meniscus; Combining; Novel

Development of a meniscal implant ex vivo will provide significant health and economic benefits, given that worldwide, millions of people annually suffer from meniscus damage or loss. We believe that a tissue engineered meniscus, composed of a novel biomimetic scaffold which guides the differentiation of mesenchymal stem cells in a novel bioreactor will provide a solution to the problem of donor scarcity in meniscal repair. Success in this project will lead directly to large-animal studies and clinical trials. The training of four early careeer researchers involved in this project will also be of significant benefit to the Australian Tissue Engineering and Biomaterials community.

考虑到全世界每年有数百万人遭受半月板损伤或损失，离体半月板植入物的开发将提供显著的健康和经济效益。 我们相信，组织工程半月板，由一种新型的仿生支架，引导间充质干细胞在一个新的生物反应器的分化，将提供一个解决的问题，供体稀缺的半月板修复。 该项目的成功将直接导致大型动物研究和临床试验。 参与该项目的四名早期职业研究人员的培训也将对澳大利亚组织工程和生物材料社区产生重大影响。