Transplanted metanephroi as functional kidneys

移植的后肾作为功能性肾脏

• 批准号: nhmrc : 511094
• 负责人: Prof Julie Campbell
• 金额: $ 20.53万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transplanted-metanephroi-functional-kidneys/101585
• 关键词: Transplanted; metanephroi; functional; kidneys

To investigate alternative strategies to treat end stage renal disease we have transplanted embryonic kidneys into the wall of the abdominal cavity of adult hosts where they become vascularised and undergo continued but limited development. Strategies to enhance their growth-development and decrease immunogenicity-rejection will now be determined, and the origin of a 'ureter-like' tube of tissue that grows to connect the transplanted embryonic kidney with the recipient bladder investigated.

为了研究治疗终末期肾病的替代策略，我们将胚胎肾移植到成年宿主的腹腔壁中，在那里它们变得血管化并经历持续但有限的发育。现在将确定促进其生长发育和减少免疫原性排斥的策略，并研究“输尿管样”组织管的起源，该组织生长以连接移植的胚胎肾与受体膀胱。