Infant-mother sleep synchrony and development of higher cognitive function

母婴睡眠同步性与高级认知功能的发展

• 批准号: 21K10891
• 负责人: 岩田 幸子
• 金额: $ 2.75万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K10891/
• 关键词: 新生児; 産後うつ; 精神疾患合併妊娠; 母児関係; 育児不安; 認知機能; 乳児概日リズム; 認知発達

乳幼児の認知機能の発達は，早産やNICU入院に代表される新生児側の因子，母体精神疾・産後うつ・育児不安などの母体側の因子，そして，母児の相互作用に強い影響を受けることが知られている．本研究は，新生児の睡眠覚醒リズムの確立過程を，睡眠同期を中心にした母児間の相互作用を通じて多面的に観察し，両者の関係性が児の遠隔期の認知機能に影響を及ぼす影響を明らかにすることを目的としている．研究初年度は，研究計画の確定，倫理委員会の承認，症例リクルートメントの開始を目標にしていたが，新型コロナウイルス感染症のアウトブレイクによる研究施設面会制限により，症例リクルートメント開始に至らなかった．その間，倫理審査及・プロトコル改定および確定・アクチグラフをはじめとする必要モニタリング機材の整備・研究協力者のトレーニングを進め，保護者の面会制限解除と共に研究が進められるように準備を整えた．幸いにも，２０２２年３月には，大半の臨床研究の再開が可能となり，研究２年度である２０２２年４月より症例リクルートメント開始予定としている．関連研究として，過去に実施した１か月健診を受診する母子約１３００人の質問紙評価のデータベースから，児の夜間覚醒に対する母親の対処行動が母児の睡眠に与える影響についての解析を進め，Scientific Reports誌に投稿・掲載した（Kuroda et al. 2021 Sci Rep.）．また，本研究の前提となるアクチグラフによる睡眠評価の妥当性を，睡眠ポリグラフを用いて評価した研究の成果を，Journal of Sleep Research誌に掲載した（Unno et al. 2022 J Sleep Res.）.

Breast-and-infant babies are aware of the high levels of knowledge, early childhood NICU admission represents the risk of birth disorder, maternal mental illness, maternal anxiety, maternal anxiety and maternal interaction. In this study, newborn babies wake up to make sure that the process is complete. During the same period of sleep, the mother-to-mother interaction in the sleep center is monitored in many ways, and the patients are aware of the impact and the impact on the purpose of the interval. at the beginning of the year of the study, the research plan is confirmed, and the committee will confirm that the case study is scheduled to begin. The equipment for the study of the new type of infectious disease will limit the number of cases from the beginning to the end of the period. during this period, the equipment is responsible for making sure that it is necessary to make sure that it is necessary to make sure that it is necessary to study the equipment equipment. The guarantor will limit the release of the study and prepare for the readjustment. Fortunately, in March 2022, more than half of the bed study may be reopened, and the study of the case study in April 2022 is scheduled to begin. Over the past few months, about 1300 mothers and children have received health care in the past few months. In the past, there have been about 1300 mothers and children who have received health care in the past few months. In the past, there have been about 1300 mothers and children who have received health care in the past few months. In the past, there have been about 1300 mothers and children who have received health care in the past few months, and about 1300 mothers and children have been invited to sleep in the past few months. during the past few months, about 1300 mothers and children have been invited to sleep at night. 2021 Sci Rep.). The premise of this study is that sleep is appropriate, sleep is appropriate, sleep is appropriate, 2022 J Sleep Res.

项目成果

Validation of actigraphy in hospitalised newborn infants using video polysomnography

使用视频多导睡眠图验证住院新生儿体动记录仪

• DOI: 10.1111/jsr.13437
• 发表时间: 2021
• 期刊: Journal of Sleep Research
• 影响因子: 4.4
• 作者: Unno Mitsuaki;Morisaki Toshihiro;Kinoshita Masahiro;Saikusa Mamoru;Iwata Sachiko;Fukaya Satoko;Yamashita Yushiro;Nakayama Meiho;Saitoh Shinji;Iwata Osuke
• 通讯作者: Iwata Osuke

Body temperature, heart rate and long-term outcome of cooled infants: an observational study

• DOI: 10.1038/s41390-021-01502-w
• 发表时间: 2021-04-12
• 期刊: PEDIATRIC RESEARCH
• 影响因子: 3.6
• 作者: Tsuda, Kennosuke;Shibasaki, Jun;Iwata, Osuke
• 通讯作者: Iwata, Osuke

Temporal changes and control variables of growth differentiation factor 15 levels during the first week of life in hospitalised newborn infants

• DOI: 10.1016/j.mito.2021.09.002
• 发表时间: 2021-09-25
• 期刊: MITOCHONDRION
• 影响因子: 4.4
• 作者: Kinoshita, Masahiro;Yatsuga, Shuichi;Koga, Yasutoshi
• 通讯作者: Koga, Yasutoshi