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Measurement of Total Energy Expenditure in Hemiplegic Patients Using Doubly Labeled Water Method and Construction of Its Prediction Equation

双标记水法测量偏瘫患者总能量消耗及其预测方程的构建

基本信息

批准号：
21K11266
负责人：
岸本浩
金额：
$ 2.75万
依托单位：
Ibaraki Prefectural University of Health Science
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2021
资助国家：
日本
起止时间：
2021-04-01 至 2025-03-31
项目状态：
未结题

项目摘要

本学付属病院回復期リハビリテーション病棟に入院する脳卒中患者のうち、意識障害、著しい高次脳機能障害、心不全、肝機能障害、腎機能障害のないこと、を条件とし、研究参加に同意した患者を対象とし、二重標識水（DLW）法による総エネルギー消費量測定を実施した。2022年度は7名の参加希望者があり、そのすべての参加者において、DLW法（水素の安定同位体（2H)からなる2H2Oと酸素の安定同位体(18O)からなるH218Oを調製、DLWとし投与する。ベースライン尿を採尿の後、DLWを摂取、1、２、７、14日後に採尿を行う。検体は安定同位体比を質量比分析計により測定し、水素と酸素の安定同位体比の減衰により二酸化炭素排出量、酸素消費量を算出し最終的に1日総エネルギー消費量(dlw-TEE)を算出）が実施された。研究参加した各症例につき、片麻痺による機能障害の程度をFugl-Meyer Assessment（FMA）により評価し、スコアリングしている①。各症例で間接熱量計により安静時消費エネルギー量(REE)を測定した②。 DLW法での測定期間中に、世界的に広く用いられ、研究実績も多い身体活動量計であるActiGraph Link GT9X(ActiGraph, 米国）を用いて身体活動に要した消費エネルギー量(PAEE)を測定した③。2022年は７例実施したが、2023年度から2024年度にかけ、20例程度実施し、DLWの結果を集積し、①②③の結果から回帰式を使って脳卒中回復期リハビリテーション中の消費エネルギーモニタリングが可能となるようにしていく。

During the return period of the affiliated hospital, patients with stroke who were admitted to the hospital were suffering from stroke, mental impairment, high-frequency mechanical impairment, heart insufficiency, liver dysfunction, mechanical dysfunction, health care, and health care. Patients who were admitted to the hospital were suffering from stroke, mental impairment, high-frequency mechanical impairment, heart insufficiency, liver dysfunction, motor dysfunction, health care, and hospitalization. in this study, patients who were admitted to the hospital were suffering from stroke, mental retardation, high-frequency mechanical impairment, cardiac insufficiency, liver dysfunction, motor dysfunction, respiratory failure, chronic stroke, stroke and stroke, heart insufficiency, liver dysfunction, liver dysfunction, stroke and stroke, heart insufficiency, liver dysfunction, In 2022, seven hopeful participants were invited to participate in the election, the DLW method (2H), the DLW method (2H), the 2H2O (18O), the H218O (18O), and the DLW (2H). The urine samples were collected by DLW after 1, 2, 7 and 14 days. The ratio of diazepam to diazepam, the amount of diacidized carbon, the amount of acid consumption, the amount of diazepam, diazepam and diazepam. In this study, we studied the degree of Fugl-Meyer Assessment (FMA) damage in patients with various symptoms, such as the degree of mechanical damage, the degree of injury, and the degree of injury. In each case, the contact volume was measured, and the REE was measured at rest. The DLW method is used to measure the number of people in the world, to measure the amount of physical activity in the world, to measure the amount of physical activity, to measure the amount of ActiGraph Link GT9X (ActiGraph, USA), to measure the amount of activity (PAEE). In 2022, in 2023, in 2024, in 2023, in 20 cases, in DLW results, in the collection of results, in 123results, in the return of stroke, in the period of recurrent stroke, in the period of recurrent stroke, it was possible to reduce the incidence of severe stroke.