ヒトMuse細胞の心筋梗塞後心筋保護効果に関する研究

人Muse细胞对心肌梗死后心肌保护作用的研究

• 批准号: 20K08400
• 负责人: 山田 好久
• 金额: $ 2.75万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K08400/
• 关键词: Muse細胞; 心筋梗塞後心不全; 心筋再生; 心機能改善; 臨床応用

う事実から、心機能回復に至る薬品や細胞治療は未だに確立されておらず、今後も臨床現場に上がると期待されるものは数少ない。そこで我々は心筋梗塞後心不全の治療法として、多能性があり腫瘍化しないMuse細胞に着目した。まずは基礎実験としてウサギより骨髄を採取し、多能性を示すSSEA3陽性のMuse細胞を分離、培養し、同じウサギの心筋梗塞後に経静脈的に（自家、Autograft）細胞移植した。これらのモデルでMuse細胞の心筋組織への生着、分化と、その心機能改善を確認した。我々は今後臨床での心筋梗塞後の心筋再生療法を推進する上で、より大型動物のブタを用いて移植されたヒトMuse細胞がその免疫寛容性や心筋への分化、組織再生に寄与するかどうかを実証するべきと考えた。実際にブタ心筋梗塞モデルを作成し、ヒト骨髄由来Muse細胞移植を行い、２週間後の心機能回復を心臓超音波検査、組織検査にて確認する。

If you don't know what to do, your heart will be able to get back to you. If you haven't been able to make sure that you don't have a problem, you can expect a small number of people on the market in the future. The treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency, the treatment of cardiac insufficiency after myocardial infarction, the treatment of cardiac insufficiency after myocardial infarction There is no significant difference between the two groups in terms of SSEA3, multipotency, isolation, culture, and transplantation of cells after myocardial infarction. It is important to ensure that the heart tissue of Muse cells is born, differentiated, and heart function can be improved. In the future, after heart muscle infarction, the method of heart muscle regeneration will be promoted, and large-scale animal products will be used to transplant Muse cells to induce differentiation, tissue regeneration and tissue regeneration. After 2 years of operation, the heart machine was able to respond to echocardiography, and the tissue tissue was able to confirm that the heart was infarcted. After 2 years, the heart machine was able to return the echocardiogram, and the tissue was able to confirm that the heart was damaged.