Bifunctional hybrid nanoparticles via calcium carbonate crystallization driven by engineered protein surfaces (A07)

通过工程蛋白质表面驱动的碳酸钙结晶实现双功能杂化纳米颗粒 (A07)

• 批准号: 313031096
• 金额: --
• 依托单位: Institut für Anorganische Chemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/313031096?language=en
• 关键词: Bifunctional; hybrid; nanoparticles; via; calcium

This project aims at the defined generation of structurally and functionally anisotropic nanohybrid particles of calcium carbonate and tailor-made genetically engineered proteins via non-classical pathways of crystallization. Iterative cycles of protein design and thorough investigations of their effect on in vitro calcium carbonate precipitation will identify the essential factors underlying this complex process. Eventually, this will pave the way for the rational generation of particle superstructures via directed self-assembly.

该项目旨在通过非经典的结晶途径确定碳酸钙和定制基因工程蛋白质的结构和功能各向异性纳米杂化颗粒的生成。蛋白质设计的迭代循环和它们对体外碳酸钙沉淀的影响的彻底调查将确定这一复杂过程的基本因素。最终，这将为通过定向自组装合理生成粒子超结构铺平道路。