Effects of fish consumption on clinical response to targeted therapies in Japanese and Spanish patients with rheumatoid arthritis

在第三年，我们对接受靶向治疗的类风湿性关节炎（RA）患者进行饮食评估，使用简短的自我管理饮食史问卷和详细的鱼类频率问卷来评估前一个月的鱼类消费。333名患者（218名日本人，115名西班牙人）返回了问卷。在研究开始时评估疾病活动性，并回顾性收集人口统计学、临床和实验室信息。在日本队列中，对124名患者进行了分析，并获得了所有临床/实验室数据。96例患者（77%）对治疗有反应。所有患者上个月均有鱼类消费，82%报告摄入富含n-3多不饱和脂肪酸（PUFAs）的鱼类（<1次/周33%，≧1次/周49%）。与无反应组相比，反应组每日从鱼类中摄取的n-3 PUFAs估计更高[中位数gr， 1.01 (IQR 0.47-1.44) vs 0.51 (IQR 0.34-1.14), p=0.044]。对来自西班牙队列的62例患者的分析，34例（55%）对治疗有反应，显示所有患者在上个月都食用鱼类，77%食用富含n-3 PUFA的鱼类（<1次/周31%，≧1次/周46%）。在这个队列中，没有观察到从鱼类中摄取n-3 PUFAs的估计差异。这些数据表明，食用鱼类可能对接受靶向治疗的日本类风湿性关节炎患者的治疗反应有积极影响。

During the third year, we completed dietary assessments in patients with rheumatoid arthritis (RA) on treatment with targeted therapies using the brief self-administered diet history questionnaire and a detailed fish frequency questionnaire to assess the fish consumption in the previous month. Three hundred and thirty-three patients (218 Japanese, 115 Spanish) returned the questionnaires. Disease activity was evaluated at study entry and demographic, clinical and laboratory information was retrospectively collected. In the Japanese cohort, an analysis was performed in 124 patients with all clinical/laboratory data available. Ninety-six patients (77%) were responders to treatment. All patients had fish consumption in the last month and 82% reported intake of n-3 polyunsaturated fatty acids (PUFAs) rich fish (<1 time/week 33%, ≧1 time/week 49%). A higher estimated daily intake of n-3 PUFAs from fish was found in the responder group compared to the non-responder group [median gr, 1.01 (IQR 0.47-1.44) vs 0.51 (IQR 0.34-1.14), p=0.044]. The analysis of 62 patients from the Spanish cohort, thirty-four (55%) responders to treatment, revealed that all patients had consumption of fish in the last month and 77% had consumed n-3 PUFA rich fish (<1 time/week 31%, ≧1 time/week 46%). No difference in estimated intake of n-3 PUFAs from fish was observed in this cohort. These data suggest that fish consumption may have a positive effect on the response to treatment in Japanese RA patients receiving targeted therapies.