Effects of fish consumption on clinical response to targeted therapies in Japanese and Spanish patients with rheumatoid arthritis

在第三年，我们完成了对类风湿性关节炎(RA)患者进行靶向治疗的饮食评估，使用了简短的自我饮食史问卷和详细的鱼类频率问卷来评估前一个月的鱼类摄入量。333名患者(日本患者218名，西班牙患者115名)收回了问卷。在研究开始时对疾病活动进行评估，并回顾收集人口统计学、临床和实验室信息。在日本的队列中，对124名患者进行了分析，获得了所有的临床/实验室数据。96名患者(77%)对治疗有反应。所有患者最近一个月都食用过鱼，82%的患者报告摄入了富含n-3多不饱和脂肪酸(≧)的鱼(&lt；1次/周33%，PUFA 1次/周49%)。与非应答者组相比，应答者组每天从鱼类中估计的n-3多不饱和脂肪酸摄入量更高[中位数GR1.01(IQR0.47-1.44)vs0.51(IQR0.34-1.14)，p=0.044]。对西班牙队列中的62名患者的分析显示，所有患者在上个月都食用了鱼类，77%的患者食用了n-3多不饱和脂肪酸含量丰富的鱼(&lt；1次/周31%，≧1次/周46%)。在这个队列中，没有观察到鱼中n-3多不饱和脂肪酸估计摄入量的差异。这些数据表明，食用鱼类可能对接受靶向治疗的日本类风湿性关节炎患者的治疗反应有积极影响。

During the third year, we completed dietary assessments in patients with rheumatoid arthritis (RA) on treatment with targeted therapies using the brief self-administered diet history questionnaire and a detailed fish frequency questionnaire to assess the fish consumption in the previous month. Three hundred and thirty-three patients (218 Japanese, 115 Spanish) returned the questionnaires. Disease activity was evaluated at study entry and demographic, clinical and laboratory information was retrospectively collected. In the Japanese cohort, an analysis was performed in 124 patients with all clinical/laboratory data available. Ninety-six patients (77%) were responders to treatment. All patients had fish consumption in the last month and 82% reported intake of n-3 polyunsaturated fatty acids (PUFAs) rich fish (<1 time/week 33%, ≧1 time/week 49%). A higher estimated daily intake of n-3 PUFAs from fish was found in the responder group compared to the non-responder group [median gr, 1.01 (IQR 0.47-1.44) vs 0.51 (IQR 0.34-1.14), p=0.044]. The analysis of 62 patients from the Spanish cohort, thirty-four (55%) responders to treatment, revealed that all patients had consumption of fish in the last month and 77% had consumed n-3 PUFA rich fish (<1 time/week 31%, ≧1 time/week 46%). No difference in estimated intake of n-3 PUFAs from fish was observed in this cohort. These data suggest that fish consumption may have a positive effect on the response to treatment in Japanese RA patients receiving targeted therapies.