Studying the dynamics of a novel small RNA (tiRNA) generation in glioma; possible new therapy

研究神经胶质瘤中新型小 RNA (tiRNA) 生成的动态；

• 批准号: 20K16323
• 负责人: Rashad Sherif
• 金额: $ 2.75万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K16323/
• 关键词: tRNA modifications; Glioma; oxidative stress; tRNA cleavage; Stroke; tRNA; CRISPR; Chemotherapy; translation; Cell Stress; Cell stress

项目成果

Mature Neurons’ sensitivity to oxidative stress is epigenetically programmed by alternative splicing and mRNA stability

成熟神经元对氧化应激的敏感性是通过选择性剪接和 mRNA 稳定性进行表观遗传编程的

• DOI: 10.1101/2021.12.25.472549
• 发表时间: 2021
• 期刊: Biorxiv preprint
• 作者: Yuan Zhou;Sherif Rashad;Teiji Tominaga;Kuniyasu Niizuma
• 通讯作者: Kuniyasu Niizuma

RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses

• DOI: 10.1177/0271678x221110679
• 发表时间: 2022-06
• 期刊: Journal of Cerebral Blood Flow & Metabolism
• 影响因子: 6.3
• 作者: Liyin Zhang;Sherif Rashad;Yuan-da Zhou;Kuniyasu Niizuma;T. Tominaga

The cell and stress‐specific canonical and noncanonical tRNA cleavage

• DOI: 10.1002/jcp.30107
• 发表时间: 2020-10
• 期刊: Journal of Cellular Physiology
• 影响因子: 5.6
• 作者: Sherif Rashad;T. Tominaga;Kuniyasu Niizuma

Epigenetic regulation of translation repression in ferroptosis, and a role of Alternative splicing and tRNA methylation

• DOI: 10.1101/2021.11.10.468143
• 发表时间: 2021-11
• 期刊: bioRxiv
• 作者: Sherif Rashad;D. Saigusa;Yuan Zhang;Liyin Zhang;T. Tominaga;Kuniyasu Niizuma