Towards improving pregnancy success rates: Understanding the functional role and memory development of CD4+ regulatory T cell subsets during first and second pregnancies.

提高妊娠成功率：了解 CD4 调节性 T 细胞亚群在第一次和第二次妊娠期间的功能作用和记忆发育。

• 批准号: 315517090
• 负责人: Professorin Dr. Petra Clara Arck
• 金额: --
• 依托单位: Klinik für Geburtshilfe und Pränatalmedizin
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/315517090?language=en
• 关键词: Towards; improving; pregnancy; success; rates

A previous successful pregnancy significantly reduces the risks for complications in subsequent pregnancies, such as spontaneous abortions, perterm birth or pre-eclampsia. Biological pathways mediating this decreased risk for pregnancy complications, despite the advanced age of the mother, are currently unknown. In the present application, we seek to identify immune markers that may account for the higher odds for successful secondary pregnancies. We will focus on the role of CD4+ regulatory T cell subsets during and between first and second pregnancies. In a basic science approach, we will utilize a variety of loss-of-function mouse models and propose objectives to test the causality between CD4+ regulatory T cell subsets and the outcome of pregnancy in step-wise, experimental functional analyses. The fate of CD4+ regulatory T cell subsets and their acquisition of memory functions is a pivotal aspect of the proposed work program. Moreover, biological samples from pregnant women during their first and second pregnancy are available to us (n=48), which shall be used to apply the findings from our basic science approach and test their relevance as diagnostic tools. We envision that these insights will allow us to generate a solid foundation on which diagnostic and therapeutic avenues can be advanced, aimimg to enhance the odds for healthy (first) pregnancies.

一次成功的怀孕大大降低了以后怀孕并发症的风险，如自然流产、早产或先兆子痫。尽管母亲年事已高，但介导妊娠并发症风险降低的生物学途径目前尚不清楚。在目前的应用中，我们试图确定免疫标记，这可能是导致二次怀孕成功率较高的原因。我们将重点关注CD4+调节性T细胞亚群在第一次和第二次怀孕期间和之间的作用。在基础科学方法中，我们将利用各种功能丧失小鼠模型，并提出目标，通过逐步的实验功能分析来测试CD4+调节性T细胞亚群与妊娠结果之间的因果关系。CD4+调节性T细胞亚群的命运及其记忆功能的获得是提出的工作计划的关键方面。此外，我们可以获得第一次和第二次怀孕的孕妇的生物样本（n=48），这些样本可以应用我们的基础科学方法的发现，并测试它们作为诊断工具的相关性。我们设想，这些见解将使我们能够建立一个坚实的基础，在此基础上可以推进诊断和治疗途径，旨在提高健康（首次）怀孕的几率。