Physiological sequences on tooth grinding under sleep-like states in animals

动物类睡眠状态下磨牙的生理序列

• 批准号: 20K18632
• 负责人: 東山 亮
• 金额: $ 2.66万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K18632/
• 关键词: ブラキシズム; 麻酔; 睡眠; 顎運動; 睡眠時ブラキシズム; 麻酔薬; 脳波; 睡眠脳波; ウレタン

ウレタン麻酔下における中枢神経の状態変化と顎運動や咀嚼筋活動との関連を調べた. ウレタン（1.4~2.0 g/kg, 腹腔内注射）麻酔下にて, 脳波, 心電図及び頸筋, 両側の咬筋, 両側の顎二腹筋前腹の筋電図, 呼吸活動, 下顎運動を記録したデータを用いて， 脳波の各周波数帯域の占有率から中枢神経の状態をNREM-like, transition, REM-like の3つに分類した.側方性の著明な顎運動が発生するため，その運動周期を周波数解析を用いて解析した.さらに，平均呼吸数や平均心拍数も算出した．脳波は高振幅徐波を特徴とする NREM-like期から, transition期を経て, 低振幅速波を特徴とする REM-like期へ移行するパターンを示したた. 顎運動は, 下顎が2 Hz～4 Hzの急速なリズミカルな反復性の運動を示す期間と, 緩徐な顎運動（0.3 Hz以下）を示す期間と顎運動を認めない期間に分類できた. 急速なリズミカルな顎運動を示す期間では, 反復性の咬筋活動が群発した. リズミカルな顎運動の41%がNREM-like期, 19.4%がtransition期, 38.9%がREM-like期に発生した．そして，リズミカルな顎運動が発生する期間は，脳波活動の睡眠周期様の変動と完全に同期していなかった. その一方で，急速なリズミカルな顎運動を示す期間では，そうでない期間と比較して，脳波活動における低周波数帯の活動性には差がないが，β帯域などの高周波帯域の活動性や，平均呼吸数が高い傾向を認めた．

The central nervous system is used to control the movement of chewing tendons. Bradykinesia (1.4-2.0 g/kg, intraperitoneal injection) convulsions, waves, heart attacks and tendons, cramp bites, cramps in the front of the two tendons, breathing activities, exercise records, wave numbers per week, wave number domain occupancy, central nervous system, NREM-like, transition, REM-like. It is important to make clear that the activity is related to the number of cycles in the cycle of the activity. The average number of respiration, the average number of heart beats, the average number of heart beats, the average number of breaths, the average number of heart beats, the average number of breaths, the average number of breaths, In the following two Hz~4 Hz programs, you can quickly check the counter-response activities during the period, and the activities (less than 0.3 Hz) will be classified during the period. We should quickly show that we are going to do some exercise during the period, and that we should do something about it in response to the crowd. 41% of the NREM-like, 19.4% of the transition, 38.9% of the REM-like were born in the same period, while the activity of the sleep cycle was completely affected. On the other hand, we should quickly tell each other that there is a period of activity, the number of waves, the number of waves.

项目成果

Changes in cortical, cardiac, and respiratory activities in relation to spontaneous rhythmic jaw movements in ketamine‐anesthetized guinea pigs

氯胺酮麻醉豚鼠皮层、心脏和呼吸活动与自发节律下颌运动相关的变化

• DOI: 10.1111/eos.12817
• 发表时间: 2021
• 期刊: European Journal of Oral Sciences
• 影响因子: 1.9
• 作者: Yano Hiroshi;Matsuura Yutaka;Katagiri Ayano;Higashiyama Makoto;Toyoda Hiroki;Sato Hajime;Ueno Yoshio;Uzawa Narikazu;Yoshida Atsushi;Kato Takafumi
• 通讯作者: Kato Takafumi