Dissecting NK cell reactivity against hepatitis B/D virus and in hepatitis C virus infection (07)

剖析 NK 细胞针对 B/D 型肝炎病毒和丙型肝炎病毒感染的反应 (07)

• 批准号: 316293312
• 金额: --
• 依托单位: Lehrstuhl für Immunbiochemie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/316293312?language=en
• 关键词: Dissecting; NK; cell; reactivity; against

The complexity of the innate immune response mediated by Natural Killer (NK) cells and other tissue-resident Innate Lymphoid Cell (ILC) subsets against different hepatitis viruses remains incompletely understood. Thus, in our project, we will study NK/ILC activation/dysfunction/exhaustion in response to HDV infection or HBV/HDV co-infection using in vitro co-culture systems and cells from hepatitis patients. Results of our study will not only facilitate the development of novel treatment options e.g. for HBV/HDV infection, but will also provide novel insight into general anti-viral mechanisms of NK cells and ILC subsets and their tissue specificity. We will further define the HCV responsive-specific NK subset and expand our previous study to different ILC subsets beyond NK cells not only from human peripheral blood, but also from human liver.

自然杀伤细胞（NK）和其他组织内固有淋巴细胞（ILC）亚群对不同肝炎病毒介导的先天免疫反应的复杂性仍然不完全清楚。因此，在我们的项目中，我们将使用体外共培养系统和肝炎患者的细胞研究NK/ILC激活/功能障碍/耗竭对HDV感染或HBV/HDV共感染的反应。我们的研究结果不仅有助于开发新的治疗方案，如HBV/HDV感染，而且还将为NK细胞和ILC亚群的一般抗病毒机制及其组织特异性提供新的见解。我们将进一步定义HCV反应特异性NK亚群，并将我们之前的研究扩展到除了NK细胞之外的不同ILC亚群，不仅来自人外周血，还来自人肝脏。