Localized FGF-receptor signaling controls differentiation of wrapping glial cells of Drosophila

局部 FGF 受体信号传导控制果蝇包裹神经胶质细胞的分化

• 批准号: 316508230
• 负责人: Professor Dr. Christian Klämbt
• 金额: --
• 依托单位: Institut für Neuro- und Verhaltensbiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/316508230?language=en
• 关键词: Localized; FGF; receptor; signaling; controls

Efficient neuronal conductance requires insulation of axons by glial cell processes. Inver-tebrates, such as Drosophila, show a relatively simple extension of glial membranes around the axons, resembling Remak fibers formed by Schwann cells in the mammalian peripheral nervous system. In the framework of tthis appliaction we want to unravel the molecular pathways underlying glial differentiation using the developing Drosophila visual system as a model. Here the wrapping glial cells first form thin processes along photore-ceptor axon fascicles to then ensheath the entire axon bundle. This differentiation is con-trolled by fibroblast growth factor (FGF)-signaling. The FGF-receptor is expressed at the neuron-glia interface along the entire length of the photoreceptor axon fascicle and is acti-vated by axonally secreted FGF. This suggests that localized activity of the FGF-receptor is important to trigger glial membrane growth around the axonal fascicle. Preliminary data suggest that additional transmembrane proteins are required for normal differentiation of the wrapping glia. We will identify these factors and address the molecular mechanisms that direct glial growth around the axon.

有效的神经元电导需要神经胶质细胞过程对轴突进行绝缘。无脊椎动物，如果蝇，在轴突周围显示出相对简单的神经胶质膜延伸，类似于哺乳动物周围神经系统中雪旺细胞形成的雷马克纤维。在此应用程序的框架中，我们希望使用发育中的果蝇视觉系统作为模型来揭示神经胶质分化的分子途径。在这里，包裹​​的神经胶质细胞首先沿着光感受器轴突束形成薄突，然后包裹整个轴突束。这种分化是由成纤维细胞生长因子（FGF）信号控制的。 FGF 受体沿着光感受器轴突束的整个长度在神经元-神经胶质细胞界面处表达，并由轴突分泌的 FGF 激活。这表明 FGF 受体的局部活性对于触发轴突束周围的神经胶质膜生长很重要。初步数据表明，包裹神经胶质细胞的正常分化需要额外的跨膜蛋白。我们将识别这些因素并解决指导轴突周围神经胶质生长的分子机制。