Functional diversity in Drosophila glial cells, the role of schlaflos and rumpel

果蝇胶质细胞的功能多样性，不眠和隆隆的作用

• 批准号: 254468921
• 负责人: Professor Dr. Christian Klämbt
• 金额: --
• 依托单位: Institut für Neuro- und Verhaltensbiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/254468921?language=en
• 关键词: Functional; diversity; Drosophila; glial; cells

Within the nervous system several classes of neuropil glia provide a range of functions for normal brain functionality. In the current proposal we aim to decipher the functional heterogeneity of the different Drosophila neuropil associated glial cells. We identified genes encoding membrane associated proteins that are required in distinct neuropil associated glial cells for normal locomotion of Drosophila flies. schlaflos (CG6927) encodes a predicted GABAA/glycine receptor and is needed for the activity behavior of the flies. The gene is expressed in only few of the neuropil-associated glial cells which will be further characterized. rumpel (CG9657) encodes a sodium-coupled monocarboxylat transporter homologous to the mammalian SLC5A family and is specifically expressed in a different subset of neuropil glial cells. The glial rumpel function is required to dampen neuronal activity upon noxious temperature stimuli. We will generate mutants of genes and will dissect their functions in glial physiology in the framework of the SPP1757.

在神经系统内，几类神经胶质细胞为正常的大脑功能提供一系列功能。在目前的建议，我们的目标是破译不同的果蝇神经胶质细胞相关的神经胶质细胞的功能异质性。我们确定了编码膜相关蛋白的基因，这些蛋白是果蝇正常运动所需的不同神经胶质细胞相关神经胶质细胞。schlavine（CG 6927）编码预测的GABAA/甘氨酸受体，并且是果蝇的活动行为所需要的。该基因仅在少数神经纤维相关神经胶质细胞中表达，这将进一步表征。rumpel（CG 9657）编码与哺乳动物SLC 5A家族同源的钠偶联单羧酸转运蛋白，并且在神经胶质细胞的不同亚群中特异性表达。神经胶质细胞的rumpel功能是必要的，以抑制神经元的活动后，有害的温度刺激。我们将产生基因的突变体，并将在SPP 1757的框架内剖析它们在神经胶质生理学中的功能。